Protein: RHBD2
Rhomboid domain-containing protein 2

Gene: RHBD2, RHBDD2
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q6NTF9

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004252 - serine-type endopeptidase activity
GO:0005047 - signal recognition particle binding
GO:0005654 - nucleoplasm
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1238158

LTMD1
LETM1 domain-containing protein 1

2

1

High-throughput

0.606

High

1238201

MLX
Max-like protein X

2

1

High-throughput

0.606

High

726816

FMO4
Dimethylaniline monooxygenase [N-oxide-forming] 4

2

0

High-throughput

0.580

High

754879

H2B1B
Histone H2B type 1-B

2

0

High-throughput

0.580

High

1125485

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

2

0

High-throughput

0.580

High

1179308

TSR1
Pre-rRNA-processing protein TSR1 homolog

2

0

High-throughput

0.580

High

1220513

MIC13
MICOS complex subunit MIC13

2

0

High-throughput

0.580

High

1238172

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

2

0

High-throughput

0.580

High

1238190

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

0

High-throughput

0.580

High

1238202

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.580

High

1238205

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

2

0

High-throughput

0.580

High

410903

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

3

High-throughput

0.576

High

396323

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

350375

ABHGA
Phosphatidylserine lipase ABHD16A

2

1

High-throughput

0.553

High

451665

TRBM
Thrombomodulin

2

4

High-throughput

0.553

High

642244

COMT
Catechol O-methyltransferase

2

1

High-throughput

0.553

High

1060181

B2CL1
Bcl-2-like protein 1

2

1

High-throughput

0.553

High

1165333

SYT16
Synaptotagmin-16

2

1

High-throughput

0.553

High

1238163

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

2

1

High-throughput

0.553

High

1238174

B2CL2
Bcl-2-like protein 2

2

1

High-throughput

0.553

High

1238192

MMRN2
Multimerin-2

2

1

High-throughput

0.553

High

1238195

DBLOH
Diablo IAP-binding mitochondrial protein

2

1

High-throughput

0.553

High

572447

DRD2
D(2) dopamine receptor

1

5

High-throughput

0.541

High

1238167

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1238176

CCD47
PAT complex subunit CCDC47

1

3

High-throughput

0.536

High

1238186

IFT27
Intraflagellar transport protein 27 homolog

1

1

High-throughput

0.536

High

931545

RD23A
UV excision repair protein RAD23 homolog A

1

2

High-throughput

0.515

High

1238193

GORS2
Golgi reassembly-stacking protein 2

1

3

High-throughput

0.515

High

1238204

NDRG4
Protein NDRG4

1

1

High-throughput

0.515

High

890004

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

861650

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

2

High-throughput

0.501

High

862223

YAP1
Transcriptional coactivator YAP1

1

7

High-throughput

0.501

High

466914

ACM4
Muscarinic acetylcholine receptor M4

1

4

High-throughput

0.494

High

669274

PTAFR
Platelet-activating factor receptor

1

6

High-throughput

0.494

High

709249

AA2AR
Adenosine receptor A2a

1

2

High-throughput

0.494

High

907090

CCR9
C-C chemokine receptor type 9

1

4

High-throughput

0.494

High

301485

WFS1
Wolframin

1

0

High-throughput

0.493

High

605719

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.493

High

1238194

MYG1
MYG1 exonuclease

1

0

High-throughput

0.493

High

1238164

ST32C
Serine/threonine-protein kinase 32C

1

1

High-throughput

0.489

High

122618

UBXN8
UBX domain-containing protein 8

1

5

High-throughput

0.479

High

373997

RASN
GTPase NRas

1

7

High-throughput

0.479

High

374685

RASH
GTPase HRas

1

7

High-throughput

0.479

High

375621

RASK
GTPase KRas

1

7

High-throughput

0.479

High

901310

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

903957

BAP31
B-cell receptor-associated protein 31

1

2

High-throughput

0.479

High

1004708

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1238160

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.479

High

1238173

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

1238189

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

1238197

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

1238203

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

46762

A0A384ME17
Elongation factor Tu

1

3

High-throughput

0.470

High

415645

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.470

High

788941

TGFR2
TGF-beta receptor type-2

1

5

High-throughput

0.470

High

895581

SERPH
Serpin H1

1

6

High-throughput

0.470

High

1050454

UBE3A
Ubiquitin-protein ligase E3A

1

4

High-throughput

0.470

High

1238159

Q6P2H7
DYNC1H1 protein

1

1

High-throughput

0.470

High

1238177

Q96AL5
PBX3 protein

1

1

High-throughput

0.470

High

1238207

RNF11
RING finger protein 11

1

1

High-throughput

0.470

High

892684

DNLI4
DNA ligase 4

1

0

High-throughput

0.460

High

327315

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

377605

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

417502

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

830923

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

1178202

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1238188

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.458

High

1238196

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1238200

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1238171

SETD6
N-lysine methyltransferase SETD6

1

1

High-throughput

0.445

High

823950

PBX3
Pre-B-cell leukemia transcription factor 3

1

1

High-throughput

0.439

High

882729

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.439

High

1123938

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.439

High

900870

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.437

High

1238157

TECT3
Tectonic-3

1

2

High-throughput

0.437

High

1238182

TECT2
Tectonic-2

1

2

High-throughput

0.437

High

380071

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

1238206

PCDGG
Protocadherin gamma-B4

1

3

High-throughput

0.407

High

155399

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

2

0

High-throughput

0.316

High

177092

SNPH
Syntaphilin

2

0

High-throughput

0.316

High

257550

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

2

0

High-throughput

0.316

High

339273

MPC2
Mitochondrial pyruvate carrier 2

2

0

High-throughput

0.316

High

658548

GCSH
Glycine cleavage system H protein, mitochondrial

2

0

High-throughput

0.316

High

663758

IL32
Interleukin-32

2

0

High-throughput

0.316

High

690709

AOFB
Amine oxidase [flavin-containing] B

2

0

High-throughput

0.316

High

694357

CO8A1
Collagen alpha-1(VIII) chain

2

0

High-throughput

0.316

High

952416

ROMO1
Reactive oxygen species modulator 1

2

0

High-throughput

0.316

High

1024383

S25A3
Solute carrier family 25 member 3

2

0

High-throughput

0.316

High

1200231

TEX44
Testis-expressed protein 44

2

0

High-throughput

0.316

High

1234415

MRM1
rRNA methyltransferase 1, mitochondrial

2

0

High-throughput

0.316

High

1238162

TPRG1
Tumor protein p63-regulated gene 1 protein

2

0

High-throughput

0.316

High

1238168

NRM
Nurim

2

0

High-throughput

0.316

High

1238175

G3ST3
Galactose-3-O-sulfotransferase 3

2

0

High-throughput

0.316

High

1238178

I27L1
Interferon alpha-inducible protein 27-like protein 1

2

0

High-throughput

0.316

High

1238179

MID49
Mitochondrial dynamics protein MID49

2

0

High-throughput

0.316

High

1238180

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

2

0

High-throughput

0.316

High

1238181

MTEF3
Transcription termination factor 3, mitochondrial

2

0

High-throughput

0.316

High

1238184

SG3A1
Secretoglobin family 3A member 1

2

0

High-throughput

0.316

High

1238185

H4G
Histone H4-like protein type G

2

0

High-throughput

0.316

High

1238187

ORNT2
Mitochondrial ornithine transporter 2

2

0

High-throughput

0.316

High

1238198

RM35
Large ribosomal subunit protein bL35m

2

0

High-throughput

0.316

High

1238208

NALD2
N-acetylated-alpha-linked acidic dipeptidase 2

2

0

High-throughput

0.316

High

1238169

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

245982

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.268

Low

1094196

ACACA
Acetyl-CoA carboxylase 1

1

0

High-throughput

0.268

Low

1216968

GDAS1
Protein GDF5-AS1, mitochondrial

1

0

High-throughput

0.268

Low

1219795

MF14C
Major facilitator superfamily domain-containing 14C pseudogene

1

0

High-throughput

0.268

Low

1229487

NCAS2
Protein NCBP2AS2

1

0

High-throughput

0.268

Low

157502

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

291385

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

293853

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1238191

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1238199

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1238161

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1238165

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1238166

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1238170

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1238183

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1139456

S39AE
Metal cation symporter ZIP14

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025