HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: DCAF1 (Q9Y4B6)
DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein)
Gene: DCAF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 1507
+	Hs
		1043326 CUL4A_HUMAN (10-768): 0: 791: 38.32		DCAF1_HUMAN (1-1507): 0: 1958: 100.00
+	Hs
		1043648 CUL4B_HUMAN (5-768): 0: 779: 36.77		DCAF1_HUMAN (1-1507): 0: 1958: 100.00
+	Mm
		56798 CUL4B_MOUSE (5-768): 0: 779: 36.64		DCAF1_MOUSE (1-1507): 0: 1921: 98.28
+	Dm
		1124380 Q5BI50_DROME (5-768): 0: 764: 37.45		DCAF1_DROME (10-1393): 0: 1421: 38.55
+	Hs
		903207 CUL3_HUMAN (1-768): 0: 951: 100.00		WDR5_HUMAN (923-1244): 5.84e-46: 171: 13.02
+	Hs
		197016 CUL3_HUMAN (1-768): 0: 951: 100.00		PRP4_HUMAN (1178-1389): 5.63e-30: 128: 11.74
+	Hs
		1042655 CUL3_HUMAN (1-768): 0: 951: 100.00		NLE1_HUMAN (972-1164): 2.95e-28: 122: 14.43
+	Hs
		929445 CUL3_HUMAN (1-768): 0: 951: 100.00		RACK1_HUMAN (1049-1209): 4.28e-28: 118: 10.86
+	Hs
		1042833 CUL3_HUMAN (1-768): 0: 951: 100.00		PRP19_HUMAN (1068-1205): 4.06e-13: 76: 14.09
+	Hs
		1042101 CUL3_HUMAN (1-768): 0: 951: 100.00		POC1B_HUMAN (1039-1120): 1.63e-10: 67.5: 12.20
+	Hs
		903208 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5_HUMAN (923-1244): 5.84e-46: 171: 13.02
+	Hs
		903209 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5_HUMAN (923-1244): 5.84e-46: 171: 13.02
+	Hs
		1043499 CUL4B_HUMAN (5-768): 0: 779: 36.77		FBXW7_HUMAN (1039-1242): 6.77e-37: 152: 9.64
+	Hs
		1043085 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5B_HUMAN (1207-1379): 3.77e-28: 119: 10.33
+	Hs
		1043441 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5B_HUMAN (1207-1379): 3.77e-28: 119: 10.33
+	Hs
		929446 CUL4B_HUMAN (5-768): 0: 779: 36.77		RACK1_HUMAN (1049-1209): 4.28e-28: 118: 10.86
+	Hs
		792982 CUL4A_HUMAN (10-768): 0: 791: 38.32		LIS1_HUMAN (1255-1393): 1.71e-14: 79.5: 10.14
+	Hs
		1043114 CUL4A_HUMAN (10-768): 0: 791: 38.32		POC1B_HUMAN (1039-1120): 1.63e-10: 67.5: 12.20
+	Hs
		1043469 CUL4B_HUMAN (5-768): 0: 779: 36.77		POC1B_HUMAN (1039-1120): 1.63e-10: 67.5: 12.20
+	At
		95048 CUL4_ARATH (8-768): 0: 744: 38.61		KTN82_ARATH (1058-1240): 1.27e-19: 97.9: 13.44