Protein: EIF3C
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)

Gene: EIF3C
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q99613

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005852 - eukaryotic translation initiation factor 3 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121858

EIF3A
Eukaryotic translation initiation factor 3 subunit A

12

5

Small-scale

0.976

High

949427

EIF3E
Eukaryotic translation initiation factor 3 subunit E

11

4

Small-scale

0.974

High

187780

EIF3D
Eukaryotic translation initiation factor 3 subunit D

10

2

Small-scale

0.970

High

131502

EIF3F
Eukaryotic translation initiation factor 3 subunit F

8

6

Small-scale

0.968

High

1271667

EIF3M
Eukaryotic translation initiation factor 3 subunit M

6

3

Small-scale

0.944

High

1405786

EIF3L
Eukaryotic translation initiation factor 3 subunit L

4

2

Small-scale

0.899

High

1405779

EIF3K
Eukaryotic translation initiation factor 3 subunit K

4

1

Small-scale

0.893

High

835116

EIF1
Eukaryotic translation initiation factor 1

2

3

Small-scale

0.777

High

128305

PSD12
26S proteasome non-ATPase regulatory subunit 12

2

0

High-throughput

0.770

High

188024

EIF3H
Eukaryotic translation initiation factor 3 subunit H

9

7

Small-scale

0.752

High

295229

EIF3G
Eukaryotic translation initiation factor 3 subunit G

8

4

Small-scale

0.751

High

939417

EIF3B
Eukaryotic translation initiation factor 3 subunit B

6

7

Small-scale

0.735

High

1102894

EIF3I
Eukaryotic translation initiation factor 3 subunit I

6

3

High-throughput

0.732

High

81731

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

1

High-throughput

0.691

High

343025

HERC2
E3 ubiquitin-protein ligase HERC2

4

1

Small-scale

0.683

High

953972

IF4A1
Eukaryotic initiation factor 4A-I

3

3

High-throughput

0.667

High

997967

CSK21
Casein kinase II subunit alpha

3

9

High-throughput

0.667

High

1047082

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

3

2

Small-scale

0.640

High

141633

DDX3X
ATP-dependent RNA helicase DDX3X

2

2

Small-scale

0.634

High

1034053

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

1

High-throughput

0.628

High

625578

CSK22
Casein kinase II subunit alpha'

2

8

High-throughput

0.611

High

1050521

UBE3A
Ubiquitin-protein ligase E3A

2

1

Small-scale

0.611

High

1137970

TNIP1
TNFAIP3-interacting protein 1

2

2

High-throughput

0.611

High

447350

NPM
Nucleophosmin

2

0

High-throughput

0.602

High

1161194

MK06
Mitogen-activated protein kinase 6

2

2

High-throughput

0.594

High

954733

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.586

High

1161616

IF16
Gamma-interferon-inducible protein 16

2

0

High-throughput

0.585

High

1124292

IF4A2
Eukaryotic initiation factor 4A-II

2

3

High-throughput

0.584

High

396786

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

631432

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

129362

MEN1
Menin

2

0

High-throughput

0.559

High

295361

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

Small-scale

0.559

High

271566

ATG13
Autophagy-related protein 13

1

1

High-throughput

0.536

High

445591

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.536

High

581577

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

698356

MAP4
Microtubule-associated protein 4

1

3

High-throughput

0.536

High

765825

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

832109

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

4

High-throughput

0.536

High

854253

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

897069

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.536

High

933350

IF5
Eukaryotic translation initiation factor 5

1

3

High-throughput

0.536

High

973552

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.536

High

992927

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

1100979

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.536

High

1136056

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

1206526

PRC2B
Protein PRRC2B

1

5

High-throughput

0.536

High

1292615

GPBP1
Vasculin

1

1

High-throughput

0.536

High

1360455

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

1405757

RBM42
RNA-binding protein 42

1

2

High-throughput

0.536

High

1405760

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.536

High

1405770

GPBL1
Vasculin-like protein 1

1

1

High-throughput

0.536

High

1405782

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

1405787

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1405788

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

High-throughput

0.536

High

1243895

AAGAB
Alpha- and gamma-adaptin-binding protein p34

1

0

High-throughput

0.518

High

831297

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

303622

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

479468

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

693926

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

859411

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

867370

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

884210

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

951374

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

970059

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1061547

ACTN3
Alpha-actinin-3

1

0

High-throughput

0.513

High

1150564

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1313589

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

1366531

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.513

High

1405126

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

1405781

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

908164

KS6A3
Ribosomal protein S6 kinase alpha-3

1

7

High-throughput

0.508

High

339837

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.500

High

867820

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

Small-scale

0.494

High

1337645

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.489

High

1405773

ENY2
Transcription and mRNA export factor ENY2

1

1

High-throughput

0.489

High

1405789

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.489

High

1405794

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.489

High

181930

SMAD9
Mothers against decapentaplegic homolog 9

1

0

High-throughput

0.486

High

1405793

TACC3
Transforming acidic coiled-coil-containing protein 3

1

1

High-throughput

0.481

High

173265

XPO1
Exportin-1

1

3

High-throughput

0.479

High

216122

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

2

High-throughput

0.479

High

242696

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

346234

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

468728

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

487674

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

505478

SLN14
Protein SLFN14 [Cleaved into: C-terminally truncated SLFN14 endoribonuclease

1

1

High-throughput

0.479

High

636137

CD11B
Cyclin-dependent kinase 11B

1

6

High-throughput

0.479

High

658620

KS6B1
Ribosomal protein S6 kinase beta-1

1

6

Small-scale

0.479

High

660710

IF4B
Eukaryotic translation initiation factor 4B

1

1

Small-scale

0.479

High

668002

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

714378

PML
Protein PML

1

2

High-throughput

0.479

High

839347

MTOR
Serine/threonine-protein kinase mTOR

1

1

Small-scale

0.479

High

861261

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.479

High

888272

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

891760

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

907553

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

930028

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

946864

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

948912

CD81
CD81 antigen

1

1

High-throughput

0.479

High

954243

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

970961

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

981042

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

995217

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

1008850

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

1040905

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

1045687

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1067636

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

1088524

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1096183

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.479

High

1100290

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1109564

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1114100

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1127104

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

1131109

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

Small-scale

0.479

High

1146463

KS6A2
Ribosomal protein S6 kinase alpha-2

1

7

High-throughput

0.479

High

1194313

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1227330

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1281593

SLN11
Schlafen family member 11

1

1

Small-scale

0.479

High

1288567

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

1290671

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

1322636

RPTOR
Regulatory-associated protein of mTOR

1

1

Small-scale

0.479

High

1337832

CSK23
Casein kinase II subunit alpha 3

1

8

High-throughput

0.479

High

1397342

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1405755

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

3

High-throughput

0.479

High

1405756

PAAF1
Proteasomal ATPase-associated factor 1

1

3

High-throughput

0.479

High

1405759

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

1405762

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.479

High

1405769

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

1405771

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

1405785

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.479

High

1405791

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

1405792

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

791654

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

125582

LEG9
Galectin-9

1

0

High-throughput

0.458

High

132252

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

238593

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

321647

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.458

High

375870

RASK
GTPase KRas

1

0

High-throughput

0.458

High

414483

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

730851

1433S
14-3-3 protein sigma

1

0

Small-scale

0.458

High

731559

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

834359

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

846439

MATR3
Matrin-3

1

0

High-throughput

0.458

High

884386

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

901518

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

905067

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

1138546

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1146784

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

1155696

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1229645

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1271807

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1289569

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1358094

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

1383027

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1388626

SPDLY
Protein Spindly

1

0

High-throughput

0.458

High

1405754

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1405764

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1405766

GAN
Gigaxonin

1

0

High-throughput

0.458

High

1405774

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1405775

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1405780

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1405783

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

1042914

ERCC6
DNA excision repair protein ERCC-6

1

2

High-throughput

0.457

High

515653

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.457

High

1405758

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

401356

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

430270

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

530268

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

935040

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

941248

IF6
Eukaryotic translation initiation factor 6

1

1

Small-scale

0.445

High

515727

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.439

High

767314

MERL
Merlin

1

0

Small-scale

0.438

High

1346899

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.438

High

106531

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

260354

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

283540

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.437

High

315927

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

427929

ICAM1
Intercellular adhesion molecule 1

1

2

High-throughput

0.437

High

589498

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

998725

H31
Histone H3.1

1

1

High-throughput

0.437

High

1094723

CAF1A
Chromatin assembly factor 1 subunit A

1

1

Small-scale

0.437

High

1096797

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1109588

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.437

High

1132923

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.437

High

1194622

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

1255215

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1380579

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.437

High

1381849

H2B1A
Histone H2B type 1-A

1

2

High-throughput

0.437

High

1401363

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

1405777

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

1405784

CD11A
Cyclin-dependent kinase 11A

1

6

High-throughput

0.437

High

567468

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

1150802

SF01
Splicing factor 1

1

0

High-throughput

0.426

High

1405772

S40A1
Ferroportin

1

0

High-throughput

0.426

High

619897

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.407

High

1405765

RSPH9
Radial spoke head protein 9 homolog

2

0

High-throughput

0.318

High

1405768

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

1395385

NEUL4
Neuralized-like protein 4

2

0

High-throughput

0.313

High

249191

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

1123531

BTG3
Protein BTG3

1

0

High-throughput

0.282

High

407124

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.279

Low

484623

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1095051

DUS4
Dual specificity protein phosphatase 4

1

0

High-throughput

0.279

Low

1405790

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

261861

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

720024

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.265

Low

1405778

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

0

Small-scale

0.265

Low

248061

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

294225

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

325066

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

372946

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

378876

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.249

Low

412496

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

607035

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

696311

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768982

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

965182

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1049194

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.249

Low

1276695

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1324055

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1332886

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1337215

MCU
Calcium uniporter protein, mitochondrial

1

0

High-throughput

0.249

Low

1352709

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1405761

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1405795

PCLO
Protein piccolo

1

0

High-throughput

0.249

Low

1405776

NUA4L
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

1

0

High-throughput

0.238

Low

62584

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

1288154

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.232

Low

1292282

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.232

Low

1405763

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

0

High-throughput

0.232

Low

1405767

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025