HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.995

The method score is based on:

Property Details
Experiments 27203177, 28886238, 30898011, 31911655, 32140073, 33536335, 18593899, 34251884, 35271311, 16964240, 16949367, 16678110, 16473935, 15448697, 20870715, 19287380, 22118460, 17626091, 10585395, 22910413 and 31 others

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Identification Methods affinity chromatography technology, pull down, two hybrid, x-ray crystallography, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CPSF_A~Cullin, Cullin~MMS1_N
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006281 - DNA repair
GO:0006974 - DNA damage response
and 8 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 759
Hs

1 1140
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ At
+ Dm
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Sp
+ Hs
+ Sp
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024