HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DCAF8 (Q5TAQ9)
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)
Gene: DCAF8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	31973889, 32235678, 21145461, 19295130, 16949367, 28514442, 31155351, 33288900, 33961781, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 597
+	Mm
		1111816 CUL4A_MOUSE (1-759): 0: 977: 95.13		DCAF8_MOUSE (1-597): 4.88e-127: 387: 95.49
+	Hs
		1043405 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCAF8_HUMAN (1-597): 5.38e-132: 400: 100.00
+	Hs
		473596 CUL4A_HUMAN (1-759): 0: 963: 100.00		DC8L2_HUMAN (1-597): 8.22e-110: 344: 65.56
+	Hs
		473597 CUL4B_HUMAN (10-759): 0: 927: 82.31		DC8L2_HUMAN (1-597): 8.22e-110: 344: 65.56
+	Hs
		1043162 CUL4A_HUMAN (1-759): 0: 963: 100.00		DCAF5_HUMAN (153-542): 6e-79: 269: 22.72
+	Mm
		1111813 CUL4A_MOUSE (1-759): 0: 977: 95.13		WDTC1_MOUSE (405-597): 3.07e-46: 175: 29.80
+	Hs
		1043102 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDTC1_HUMAN (405-597): 4.23e-46: 174: 30.30
+	Hs
		1043157 CUL4A_HUMAN (1-759): 0: 963: 100.00		SNR40_HUMAN (83-358): 2.66e-47: 171: 14.69
+	Hs
		903208 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Hs
		1043032 CUL4A_HUMAN (1-759): 0: 963: 100.00		DCAF6_HUMAN (415-576): 1.36e-40: 159: 36.36
+	Hs
		903209 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Hs
		1043396 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCAF6_HUMAN (415-576): 1.36e-40: 159: 36.36
+	Hs
		1043114 CUL4A_HUMAN (1-759): 0: 963: 100.00		POC1B_HUMAN (464-588): 4.92e-28: 119: 15.08
+	Hs
		245601 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL1X_HUMAN (365-588): 1.06e-37: 149: 9.87
+	Hs
		1043085 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5B_HUMAN (466-589): 5.53e-21: 96.2: 15.20
+	Hs
		1043068 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR82_HUMAN (329-546): 8.72e-13: 71.4: 10.90
+	Hs
		1043441 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5B_HUMAN (466-589): 5.53e-21: 96.2: 15.20
+	Hs
		792982 CUL4A_HUMAN (1-759): 0: 963: 100.00		LIS1_HUMAN (505-582): 6.91e-09: 60: 11.54
+	Hs
		1043419 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR82_HUMAN (329-546): 8.72e-13: 71.4: 10.90
+	Hs
		1016274 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL3_HUMAN (76-182): 1.35e-09: 63: 9.35