Protein: IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)

Gene: IKKB, Ikbkb
Organism: Mus musculus
Interactions: 60
UniProt ID: O88351

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

291432

NEMO
NF-kappa-B essential modulator

18

17

Small-scale

0.984

High

291486

IKBA
NF-kappa-B inhibitor alpha

4

20

Small-scale

0.885

High

291461

IKBB
NF-kappa-B inhibitor beta

4

20

Small-scale

0.882

High

291460

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

4

19

Small-scale

0.873

High

291465

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

7

Small-scale

0.768

High

291441

AKT1
RAC-alpha serine/threonine-protein kinase

2

20

Small-scale

0.754

High

291431

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

18

Small-scale

0.724

High

291437

TNR1A
Tumor necrosis factor receptor superfamily member 1A

4

17

Small-scale

0.676

High

291472

OPTN
Optineurin

1

20

Small-scale

0.647

High

86489

NLRC5
Protein NLRC5

1

12

Small-scale

0.618

High

291433

CASP8
Caspase-8

1

6

Small-scale

0.618

High

291446

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

20

Small-scale

0.618

High

291447

SASH1
SAM and SH3 domain-containing protein 1

1

2

Small-scale

0.618

High

291455

KPCT
Protein kinase C theta type

1

20

Small-scale

0.618

High

291462

ACVL1
Serine/threonine-protein kinase receptor R3

1

8

High-throughput

0.618

High

291466

TGFR2
TGF-beta receptor type-2

1

7

High-throughput

0.618

High

291471

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

20

Small-scale

0.618

High

291478

RHOA
Transforming protein RhoA

1

9

Small-scale

0.618

High

291480

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

18

Small-scale

0.618

High

291483

TBK1
Serine/threonine-protein kinase TBK1

1

18

Small-scale

0.618

High

291484

KS6A2
Ribosomal protein S6 kinase alpha-2

1

17

Small-scale

0.618

High

291468

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

11

High-throughput

0.590

High

291435

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

20

High-throughput

0.579

High

291449

RACK1
Small ribosomal subunit protein RACK1

2

6

Small-scale

0.576

High

291452

NKX32
Homeobox protein Nkx-3.2

1

2

Small-scale

0.561

High

291458

KLH21
Kelch-like protein 21

1

6

Small-scale

0.561

High

140166

SNP23
Synaptosomal-associated protein 23

2

2

Small-scale

0.533

High

291439

TNR5
Tumor necrosis factor receptor superfamily member 5

1

17

Small-scale

0.515

High

291451

IRF7
Interferon regulatory factor 7

1

14

Small-scale

0.515

High

291434

TNFA
Tumor necrosis factor

1

6

Small-scale

0.479

High

291436

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

Small-scale

0.479

High

291442

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

8

Small-scale

0.479

High

291443

HES1
Transcription factor HES-1

1

1

Small-scale

0.479

High

291444

LIT1
Lithostathine-1

1

1

Small-scale

0.479

High

291448

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

12

Small-scale

0.479

High

291450

TANK
TRAF family member-associated NF-kappa-B activator

1

5

Small-scale

0.479

High

291453

SMN
Survival motor neuron protein

1

5

Small-scale

0.479

High

291456

TF65
Transcription factor p65

1

17

Small-scale

0.479

High

291457

STING
Stimulator of interferon genes protein

1

5

High-throughput

0.479

High

291459

FBW1A
F-box/WD repeat-containing protein 1A

1

12

Small-scale

0.479

High

291474

RNF31
E3 ubiquitin-protein ligase RNF31

1

8

Small-scale

0.479

High

291482

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

10

Small-scale

0.479

High

291469

FACD2
Fanconi anemia group D2 protein homolog

1

0

High-throughput

0.458

High

291438

CTNA1
Catenin alpha-1

1

4

High-throughput

0.457

High

291454

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.457

High

291463

DDX5
Probable ATP-dependent RNA helicase DDX5

1

4

High-throughput

0.457

High

291464

CREB3
Cyclic AMP-responsive element-binding protein 3

1

20

High-throughput

0.457

High

291473

5MP1
eIF5-mimic protein 1

1

1

High-throughput

0.457

High

291485

SNX1
Sorting nexin-1

1

1

High-throughput

0.457

High

291487

KEAP1
Kelch-like ECH-associated protein 1

1

3

High-throughput

0.457

High

291445

TNR4
Tumor necrosis factor receptor superfamily member 4

1

17

Small-scale

0.457

High

291470

GMPPB
Mannose-1-phosphate guanyltransferase beta

1

0

High-throughput

0.438

High

291477

SAS10
Something about silencing protein 10

1

0

High-throughput

0.438

High

291479

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.438

High

291475

CUED2
CUE domain-containing protein 2

1

2

Small-scale

0.437

High

291440

GSTA3
Glutathione S-transferase A3

1

4

High-throughput

0.417

High

291481

SCNNB
Amiloride-sensitive sodium channel subunit beta

1

0

Small-scale

0.264

Low

291467

SDC3
Syndecan-3

1

0

High-throughput

0.238

Low

291476

T2EB
General transcription factor IIE subunit 2

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024