HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DCNL2 (Q6PH85)
DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)
Gene: DCUN1D2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	36688959, 23201271, 26906416, 19617556
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~Cullin_binding
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 259
+	Hs
		1043159 CUL4A_HUMAN (1-759): 0: 963: 100.00		DCNL1_HUMAN (1-257): 7.01e-132: 374: 78.21
+	Hs
		1043412 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCNL2_HUMAN (1-259): 1.23e-132: 376: 100.00
+	Hs
		1043514 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCNL1_HUMAN (1-257): 7.01e-132: 374: 78.21
+	Hs
		1043133 CUL4A_HUMAN (1-759): 0: 963: 100.00		DCNL4_HUMAN (42-250): 1.37e-90: 271: 34.45
+	Hs
		1043197 CUL4A_HUMAN (1-759): 0: 963: 100.00		DCNL5_HUMAN (55-248): 4.09e-86: 258: 34.54
+	Hs
		1043091 CUL4A_HUMAN (1-759): 0: 963: 100.00		DCNL3_HUMAN (53-246): 4.59e-84: 254: 45.77
+	Hs
		1043486 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCNL4_HUMAN (42-250): 1.37e-90: 271: 34.45
+	Hs
		1041837 CUL3_HUMAN (32-759): 0: 814: 38.23		DCNL2_HUMAN (1-259): 1.23e-132: 376: 100.00
+	Hs
		1042270 CUL3_HUMAN (32-759): 0: 814: 38.23		DCNL1_HUMAN (1-257): 7.01e-132: 374: 78.21
+	Hs
		1043549 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCNL5_HUMAN (55-248): 4.09e-86: 258: 34.54
+	Hs
		1043445 CUL4B_HUMAN (10-759): 0: 927: 82.31		DCNL3_HUMAN (53-246): 4.59e-84: 254: 45.77
+	Dm
		1124377 Q5BI50_DROME (27-759): 0: 877: 65.90		DCNL3_DROME (37-254): 3.04e-83: 254: 37.22
+	Hs
		1041051 CUL1_HUMAN (59-759): 0: 745: 30.55		DCNL2_HUMAN (1-259): 1.23e-132: 376: 100.00
+	Hs
		1041145 CUL1_HUMAN (59-759): 0: 745: 30.55		DCNL1_HUMAN (1-257): 7.01e-132: 374: 78.21
+	Hs
		1042176 CUL3_HUMAN (32-759): 0: 814: 38.23		DCNL4_HUMAN (42-250): 1.37e-90: 271: 34.45
+	Hs
		1042423 CUL3_HUMAN (32-759): 0: 814: 38.23		DCNL5_HUMAN (55-248): 4.09e-86: 258: 34.54
+	Hs
		1041979 CUL3_HUMAN (32-759): 0: 814: 38.23		DCNL3_HUMAN (53-246): 4.59e-84: 254: 45.77
+	Hs
		1041123 CUL1_HUMAN (59-759): 0: 745: 30.55		DCNL4_HUMAN (42-250): 1.37e-90: 271: 34.45
+	Hs
		1041180 CUL1_HUMAN (59-759): 0: 745: 30.55		DCNL5_HUMAN (55-248): 4.09e-86: 258: 34.54
+	Hs
		1041081 CUL1_HUMAN (59-759): 0: 745: 30.55		DCNL3_HUMAN (53-246): 4.59e-84: 254: 45.77