HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.749

Property	Details
Experiments	17041588, 17079684, 21145461, 19295130, 14739464, 32041890, 37689310, 25117710
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 731
+	Mm
		1111821 CUL4A_MOUSE (1-759): 0: 977: 95.13		COP1_MOUSE (1-731): 3.36e-168: 503: 96.86
+	Hs
		1043464 CUL4B_HUMAN (10-759): 0: 927: 82.31		COP1_HUMAN (1-731): 0: 540: 100.00
+	Mm
		56803 CUL4B_MOUSE (10-759): 0: 927: 82.18		COP1_MOUSE (1-731): 3.36e-168: 503: 96.86
+	Hs
		1043085 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79
+	Hs
		1043499 CUL4B_HUMAN (10-759): 0: 927: 82.31		FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15
+	Hs
		792982 CUL4A_HUMAN (1-759): 0: 963: 100.00		LIS1_HUMAN (509-730): 2.11e-55: 197: 21.24
+	Hs
		1043441 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5B_HUMAN (336-625): 1.65e-63: 216: 17.79
+	Hs
		997714 CUL4A_HUMAN (1-759): 0: 963: 100.00		RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49
+	Hs
		903208 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Hs
		1043114 CUL4A_HUMAN (1-759): 0: 963: 100.00		POC1B_HUMAN (627-728): 3.91e-13: 74.5: 18.63
+	Hs
		1043016 CUL4A_HUMAN (1-759): 0: 963: 100.00		RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34
+	Hs
		1043157 CUL4A_HUMAN (1-759): 0: 963: 100.00		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67
+	Hs
		997715 CUL4B_HUMAN (10-759): 0: 927: 82.31		RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49
+	Hs
		903209 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Hs
		1043469 CUL4B_HUMAN (10-759): 0: 927: 82.31		POC1B_HUMAN (627-728): 3.91e-13: 74.5: 18.63
+	Hs
		1043376 CUL4B_HUMAN (10-759): 0: 927: 82.31		RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34
+	Hs
		1043509 CUL4B_HUMAN (10-759): 0: 927: 82.31		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67
+	At
		794481 CUL4_ARATH (24-759): 0: 861: 57.40		COP1_ARATH (512-730): 3.95e-30: 128: 17.67
+	Hs
		197016 CUL3_HUMAN (32-759): 0: 814: 38.23		PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59
+	Hs
		903207 CUL3_HUMAN (32-759): 0: 814: 38.23		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18