HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: PHIP (Q8WWQ0)
PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)
Gene: PHIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.755

Property	Details
Experiments	16949367, 29089422, 30018425, 31911655, 33503431, 34171797, 37689310, 31973889, 16964240, 21145461, 19295130
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 1821
+	Hs
		1043478 CUL4B_HUMAN (10-759): 0: 927: 82.31		PHIP_HUMAN (1-1821): 0: 1502: 100.00
+	Hs
		1016274 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL3_HUMAN (7-495): 2.68e-90: 315: 14.31
+	Hs
		903208 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5_HUMAN (352-664): 2.63e-65: 227: 16.62
+	Hs
		1043114 CUL4A_HUMAN (1-759): 0: 963: 100.00		POC1B_HUMAN (7-255): 7.7e-55: 201: 13.20
+	Hs
		1043157 CUL4A_HUMAN (1-759): 0: 963: 100.00		SNR40_HUMAN (355-666): 5.05e-55: 198: 13.23
+	Hs
		903209 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5_HUMAN (352-664): 2.63e-65: 227: 16.62
+	Hs
		152876 CUL4B_HUMAN (10-759): 0: 927: 82.31		APAF_HUMAN (305-887): 1.12e-58: 225: 11.63
+	Hs
		1043085 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5B_HUMAN (422-708): 3.76e-50: 183: 11.41
+	Hs
		1043499 CUL4B_HUMAN (10-759): 0: 927: 82.31		FBXW7_HUMAN (294-657): 3.51e-56: 211: 17.33
+	Hs
		1043562 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL1R_HUMAN (299-580): 2.26e-57: 210: 13.71
+	Hs
		1043252 CUL4A_HUMAN (1-759): 0: 963: 100.00		BRWD1_HUMAN (1-298): 6.14e-41: 168: 15.76
+	Hs
		1043469 CUL4B_HUMAN (10-759): 0: 927: 82.31		POC1B_HUMAN (7-255): 7.7e-55: 201: 13.20
+	Hs
		1043064 CUL4A_HUMAN (1-759): 0: 963: 100.00		BRWD3_HUMAN (1-298): 2.1e-39: 163: 13.65
+	Hs
		1043509 CUL4B_HUMAN (10-759): 0: 927: 82.31		SNR40_HUMAN (355-666): 5.05e-55: 198: 13.23
+	Hs
		1043441 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5B_HUMAN (422-708): 3.76e-50: 183: 11.41
+	Hs
		792982 CUL4A_HUMAN (1-759): 0: 963: 100.00		LIS1_HUMAN (354-552): 3.25e-33: 136: 18.00
+	Hs
		1043611 CUL4B_HUMAN (10-759): 0: 927: 82.31		BRWD1_HUMAN (1-298): 6.14e-41: 168: 15.76
+	Hs
		1043417 CUL4B_HUMAN (10-759): 0: 927: 82.31		BRWD3_HUMAN (1-298): 2.1e-39: 163: 13.65
+	Hs
		245601 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL1X_HUMAN (423-696): 1.86e-26: 118: 13.03
+	Hs
		152875 CUL3_HUMAN (32-759): 0: 814: 38.23		APAF_HUMAN (305-887): 1.12e-58: 225: 11.63