HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DDB2 (Q92466)
DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)
Gene: DDB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.769

The method score is based on:

Property Details
Experiments 30945288, 31973889, 33759138, 18593899, 16964240, 17041588, 11564859, 17079684, 21145461, 16260596, 19295130, 16949367, 12732143, 26186194, 26496610, 16751180, 27203177, 28514442, 28035050, 29262658 and 11 others

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Identification Methods affinity chromatography technology, enzymatic study, pull down, proximity labelling technology, biochemical, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
GO:0006974 - DNA damage response
GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex
and 2 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 759
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Last updated: 15 Jul 2024