HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: WDR76 (Q9H967)
WD repeat-containing protein 76
Gene: WDR76

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	30655611, 17041588
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006974 - DNA damage response GO:2000001 - regulation of DNA damage checkpoint
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 626
+	Mm
		1111821 CUL4A_MOUSE (1-759): 0: 977: 95.13		COP1_MOUSE (154-619): 4.46e-68: 237: 14.58
+	Hs
		1043111 CUL4A_HUMAN (1-759): 0: 963: 100.00		COP1_HUMAN (154-619): 7.6e-71: 245: 14.96
+	Hs
		1043128 CUL4A_HUMAN (1-759): 0: 963: 100.00		DDB2_HUMAN (201-625): 1.38e-70: 236: 21.51
+	Hs
		1043464 CUL4B_HUMAN (10-759): 0: 927: 82.31		COP1_HUMAN (154-619): 7.6e-71: 245: 14.96
+	Hs
		1027994 CUL4A_HUMAN (1-759): 0: 963: 100.00		ERCC8_HUMAN (305-532): 1.35e-57: 200: 19.92
+	Hs
		1043483 CUL4B_HUMAN (10-759): 0: 927: 82.31		DDB2_HUMAN (201-625): 1.38e-70: 236: 21.51
+	Hs
		1043499 CUL4B_HUMAN (10-759): 0: 927: 82.31		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		792982 CUL4A_HUMAN (1-759): 0: 963: 100.00		LIS1_HUMAN (118-478): 6.33e-51: 183: 9.73
+	Hs
		1043085 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5B_HUMAN (395-624): 2.14e-51: 182: 11.74
+	Hs
		1027995 CUL4B_HUMAN (10-759): 0: 927: 82.31		ERCC8_HUMAN (305-532): 1.35e-57: 200: 19.92
+	Hs
		903208 CUL4A_HUMAN (1-759): 0: 963: 100.00		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		1043114 CUL4A_HUMAN (1-759): 0: 963: 100.00		POC1B_HUMAN (435-626): 4.48e-37: 146: 12.95
+	Hs
		1043441 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5B_HUMAN (395-624): 2.14e-51: 182: 11.74
+	Hs
		1043157 CUL4A_HUMAN (1-759): 0: 963: 100.00		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Hs
		903209 CUL4B_HUMAN (10-759): 0: 927: 82.31		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		245601 CUL4B_HUMAN (10-759): 0: 927: 82.31		TBL1X_HUMAN (248-479): 3.7e-39: 153: 13.67
+	Hs
		1043469 CUL4B_HUMAN (10-759): 0: 927: 82.31		POC1B_HUMAN (435-626): 4.48e-37: 146: 12.95
+	Hs
		1043509 CUL4B_HUMAN (10-759): 0: 927: 82.31		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	Hs
		997714 CUL4A_HUMAN (1-759): 0: 963: 100.00		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		997715 CUL4B_HUMAN (10-759): 0: 927: 82.31		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55