Protein: TAP2
Antigen peptide transporter 2 (APT2) (EC 7.4.2.14) (ATP-binding cassette sub-family B member 3) (Peptide supply factor 2) (Peptide transporter PSF2) (PSF-2) (Peptide transporter TAP2) (Peptide transporter involved in antigen processing 2) (Really interesting new gene 11 protein) (RING11)

Gene: TAP2
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q03519

Gene Ontology (top 5):
GO:0001913 - T cell mediated cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002237 - response to molecule of bacterial origin
GO:0002481 - antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0002485 - antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1043116

TAP1
Antigen peptide transporter 1

12

15

Small-scale

0.978

High

563656

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.691

High

1043229

GWL
Serine/threonine-protein kinase greatwall

1

1

High-throughput

0.691

High

1043198

TAP2
Antigen peptide transporter 2

1

15

Small-scale

0.647

High

142128

NPT3
Sodium-dependent phosphate transport protein 3

2

1

High-throughput

0.628

High

1043217

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

2

High-throughput

0.628

High

193696

TPSN
Tapasin

2

6

Small-scale

0.624

High

1043227

RN185
E3 ubiquitin-protein ligase RNF185

2

4

Small-scale

0.611

High

902347

SCNND
Epithelial sodium channel subunit delta

2

0

High-throughput

0.602

High

332974

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

2

High-throughput

0.601

High

1043232

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

6

High-throughput

0.601

High

409358

HLAA
HLA class I histocompatibility antigen, A alpha chain

2

9

Small-scale

0.584

High

855316

5HT3A
5-hydroxytryptamine receptor 3A

2

4

High-throughput

0.574

High

867613

GPR12
G-protein coupled receptor 12

2

8

High-throughput

0.549

High

182514

GP182
G-protein coupled receptor 182

1

16

High-throughput

0.536

High

183922

S22A2
Solute carrier family 22 member 2

1

8

High-throughput

0.536

High

260750

RAMP2
Receptor activity-modifying protein 2

1

4

High-throughput

0.536

High

292343

RA51D
DNA repair protein RAD51 homolog 4

1

1

High-throughput

0.536

High

547317

CP19A
Aromatase

1

2

High-throughput

0.536

High

595039

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

5

High-throughput

0.536

High

698597

CALX
Calnexin

1

6

High-throughput

0.536

High

784823

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

2

High-throughput

0.536

High

1043200

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

5

High-throughput

0.536

High

1043201

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

2

High-throughput

0.536

High

1043204

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

1

High-throughput

0.536

High

1043205

CKAP5
Cytoskeleton-associated protein 5

1

2

High-throughput

0.536

High

1043206

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

2

High-throughput

0.536

High

1043210

PTHD3
Patched domain-containing protein 3

1

4

High-throughput

0.536

High

1043213

TTMP
TPA-induced transmembrane protein

1

3

High-throughput

0.536

High

1043215

ATLA3
Atlastin-3

1

1

High-throughput

0.536

High

1043221

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

3

High-throughput

0.536

High

1043226

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

3

High-throughput

0.536

High

1043238

RXFP1
Relaxin receptor 1

1

2

High-throughput

0.536

High

1043244

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

2

High-throughput

0.536

High

568055

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

9

Small-scale

0.515

High

230953

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

1043224

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

421963

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

388121

ACHA
Acetylcholine receptor subunit alpha

1

2

High-throughput

0.489

High

407167

CD3D
T-cell surface glycoprotein CD3 delta chain

1

1

High-throughput

0.489

High

914529

EFNA5
Ephrin-A5

1

1

High-throughput

0.489

High

1043202

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

11

High-throughput

0.489

High

1043203

KLRD1
Natural killer cells antigen CD94

1

11

High-throughput

0.489

High

1043218

LRC55
Leucine-rich repeat-containing protein 55

1

2

High-throughput

0.489

High

1043220

TMM25
Transmembrane protein 25

1

1

High-throughput

0.489

High

1043239

KCMB3
Calcium-activated potassium channel subunit beta-3

1

1

High-throughput

0.489

High

1043241

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

3

High-throughput

0.489

High

1043245

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

1

High-throughput

0.489

High

1043246

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

2

High-throughput

0.489

High

1043248

PTC2
Protein patched homolog 2

1

4

High-throughput

0.489

High

241454

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

283238

ERLN1
Erlin-1

1

1

Small-scale

0.479

High

321223

ERLN2
Erlin-2

1

6

Small-scale

0.479

High

337584

FMNL1
Formin-like protein 1

1

3

Small-scale

0.479

High

420501

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

9

Small-scale

0.479

High

520819

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

9

Small-scale

0.479

High

598068

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

9

Small-scale

0.479

High

607364

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

9

Small-scale

0.479

High

714049

PML
Protein PML

1

1

High-throughput

0.479

High

934496

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

963500

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

16

Small-scale

0.479

High

1043225

FAF2
FAS-associated factor 2

1

1

Small-scale

0.479

High

1043231

RNF5
E3 ubiquitin-protein ligase RNF5

1

4

Small-scale

0.479

High

1043236

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.479

High

1043240

DJB12
DnaJ homolog subfamily B member 12

1

6

Small-scale

0.479

High

1043243

AMFR
E3 ubiquitin-protein ligase AMFR

1

2

Small-scale

0.479

High

700452

PSB8
Proteasome subunit beta type-8

1

5

Small-scale

0.464

High

1043222

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

Small-scale

0.458

High

1043242

DJB11
DnaJ homolog subfamily B member 11

1

0

Small-scale

0.458

High

380008

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

9

High-throughput

0.445

High

538748

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

6

High-throughput

0.445

High

869585

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

7

High-throughput

0.445

High

1043207

S39AE
Metal cation symporter ZIP14

1

13

High-throughput

0.445

High

1043214

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

218084

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

533924

IRF1
Interferon regulatory factor 1

1

3

Small-scale

0.437

High

1004471

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

1043199

TF65
Transcription factor p65

1

3

Small-scale

0.437

High

1043208

P2RY6
P2Y purinoceptor 6

1

17

High-throughput

0.437

High

1043216

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

1043219

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1043228

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

1043237

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1043209

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

700513

PSB9
Proteasome subunit beta type-9

1

5

Small-scale

0.417

High

653268

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.407

High

1043212

S39AC
Zinc transporter ZIP12

1

13

High-throughput

0.407

High

1043223

ZNT7
Zinc transporter 7

1

6

High-throughput

0.407

High

1043233

S39A3
Zinc transporter ZIP3

1

13

High-throughput

0.407

High

1043230

RBM18
Probable RNA-binding protein 18

1

0

High-throughput

0.282

High

1043234

PSMG3
Proteasome assembly chaperone 3

1

0

High-throughput

0.282

High

1023014

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

0

High-throughput

0.279

Low

1043211

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

1043247

ZN281
Zinc finger protein 281

1

0

High-throughput

0.279

Low

1043235

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.275

Low


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Last updated: 11Aug2025