HitPredict

Interactor 1: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1128 Hs			1 665
+	Hs
		985571 Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		924553 ASPP2_HUMAN (1-1128): 0: 599: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		1043658 ASPP2_HUMAN (1-1128): 0: 599: 100.00		ARHG6_HUMAN (218-345): 4.37e-16: 84.3: 24.81
+	Hs
		1043687 ASPP2_HUMAN (1-1128): 0: 599: 100.00		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Hs
		985543 Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90		ARHG6_HUMAN (218-345): 4.37e-16: 84.3: 24.81
+	Dm
		1196986 Q86BG1_DROME (126-1123): 1.08e-74: 270: 27.13		Q9VA36_DROME (2-576): 1.83e-50: 190: 22.53
+	Hs
		235524 KANK2_HUMAN (303-1049): 2.35e-63: 234: 16.00		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Dm
		1214884 Q8IQN4_DROME (940-1034): 1.71e-11: 71: 31.25		Q9VIN1_DROME (2-656): 1.03e-49: 186: 16.50
+	Hs
		1078843 ANR54_HUMAN (902-1045): 1.27e-39: 151: 31.97		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		208966 PSD10_HUMAN (988-1128): 3e-43: 159: 16.77		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		235529 ANR54_HUMAN (902-1045): 1.27e-39: 151: 31.97		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		557772 EHMT2_HUMAN (687-995): 4.44e-17: 89.1: 10.35		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924794 EHMT2_HUMAN (687-995): 4.44e-17: 89.1: 10.35		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		161352 MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		1349277 DAPLE_HUMAN (33-349): 6.45e-16: 85.6: 16.36		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		161301 MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Ce
		105099 G5ECD7_CAEEL (931-1059): 2.42e-13: 76.8: 29.41		Q9U2T9_CAEEL (142-349): 4.59e-14: 78.1: 18.48