Protein: NLE1
Notchless protein homolog 1

Gene: NLE1
Organism: Homo sapiens
Interactions: 201
UniProt ID: Q9NVX2

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0001756 - somitogenesis
GO:0001822 - kidney development
GO:0001826 - inner cell mass cell differentiation
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1450942

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

2

7

High-throughput

0.754

High

984561

RL30
Large ribosomal subunit protein eL30

2

2

High-throughput

0.726

High

338195

NSA2
Ribosome biogenesis protein NSA2 homolog

5

2

High-throughput

0.712

High

876199

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.705

High

1007305

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.705

High

1418618

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

4

6

High-throughput

0.694

High

1450940

H2AW
Core histone macro-H2A.2

1

9

High-throughput

0.691

High

1199157

PKHO1
Pleckstrin homology domain-containing family O member 1

2

0

High-throughput

0.679

High

1413135

THAP7
THAP domain-containing protein 7

3

2

High-throughput

0.667

High

96776

E9PAV9
G patch domain-containing protein 4

3

3

High-throughput

0.640

High

807965

SMBP2
DNA-binding protein SMUBP-2

2

3

High-throughput

0.628

High

905194

MECP2
Methyl-CpG-binding protein 2

2

4

High-throughput

0.628

High

1057927

RL18
Large ribosomal subunit protein eL18

2

3

High-throughput

0.628

High

1416130

RBM4
RNA-binding protein 4

2

9

High-throughput

0.628

High

224376

BUB3
Mitotic checkpoint protein BUB3

1

18

High-throughput

0.618

High

257980

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

3

High-throughput

0.618

High

316325

RECQ5
ATP-dependent DNA helicase Q5

1

13

High-throughput

0.618

High

899608

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.618

High

926419

BLM
RecQ-like DNA helicase BLM

1

13

High-throughput

0.618

High

975981

RL7A
Large ribosomal subunit protein eL8

1

6

High-throughput

0.618

High

992995

RACK1
Small ribosomal subunit protein RACK1

1

17

High-throughput

0.618

High

1083446

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

9

High-throughput

0.618

High

1088581

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

9

High-throughput

0.618

High

1121092

BOP1
Ribosome biogenesis protein BOP1

1

18

High-throughput

0.618

High

1130862

RRP5
Protein RRP5 homolog

1

6

High-throughput

0.618

High

1148066

SF3B3
Splicing factor 3B subunit 3

1

9

High-throughput

0.618

High

1212047

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

16

High-throughput

0.618

High

1369406

DDX17
Probable ATP-dependent RNA helicase DDX17

1

7

High-throughput

0.618

High

1392247

DDX27
Probable ATP-dependent RNA helicase DDX27

1

14

High-throughput

0.618

High

1419379

SETD2
Histone-lysine N-methyltransferase SETD2

1

3

High-throughput

0.618

High

1428555

DDX24
ATP-dependent RNA helicase DDX24

1

16

High-throughput

0.618

High

1434039

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.618

High

1436289

DDX31
ATP-dependent DNA helicase DDX31

1

12

High-throughput

0.618

High

1447333

ANLN
Anillin

1

2

High-throughput

0.618

High

1450936

NLE1
Notchless protein homolog 1

1

15

High-throughput

0.618

High

824389

RL13A
Large ribosomal subunit protein uL13

2

4

High-throughput

0.611

High

1117686

NOG2
Nucleolar GTP-binding protein 2

2

7

High-throughput

0.611

High

1415554

GNL3
Guanine nucleotide-binding protein-like 3

2

7

High-throughput

0.611

High

1447994

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.586

High

1450945

NOL12
Nucleolar protein 12

2

0

High-throughput

0.585

High

373290

MYC
Myc proto-oncogene protein

2

15

High-throughput

0.584

High

1449705

MDN1
Midasin

2

12

Small-scale

0.584

High

477179

ACM5
Muscarinic acetylcholine receptor M5

1

0

High-throughput

0.584

High

960915

RL15
Large ribosomal subunit protein eL15

2

3

High-throughput

0.574

High

977095

CNBP
CCHC-type zinc finger nucleic acid binding protein

2

3

High-throughput

0.574

High

1130485

RRP1B
Ribosomal RNA processing protein 1 homolog B

2

4

High-throughput

0.571

High

821597

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.553

High

1255786

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

1350213

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

5

High-throughput

0.553

High

1407594

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.553

High

1033267

EWS
RNA-binding protein EWS

1

5

High-throughput

0.541

High

287163

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

9

High-throughput

0.536

High

288793

NPM3
Nucleoplasmin-3

1

6

High-throughput

0.536

High

447501

NPM
Nucleophosmin

1

6

High-throughput

0.536

High

898853

RL14
Large ribosomal subunit protein eL14

1

2

High-throughput

0.536

High

1008909

RED1
Double-stranded RNA-specific editase 1

1

5

High-throughput

0.536

High

1016642

SRSF3
Serine/arginine-rich splicing factor 3

1

18

High-throughput

0.536

High

1099276

SRSF5
Serine/arginine-rich splicing factor 5

1

11

High-throughput

0.536

High

1114438

CUL3
Cullin-3

1

19

High-throughput

0.536

High

1287785

NOP9
Nucleolar protein 9

1

2

High-throughput

0.536

High

1409857

RBM4B
RNA-binding protein 4B

1

9

High-throughput

0.536

High

1410750

MBB1A
Myb-binding protein 1A

1

2

High-throughput

0.536

High

1450938

LYAR
Cell growth-regulating nucleolar protein

1

3

High-throughput

0.536

High

243097

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.533

High

837871

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

2

2

High-throughput

0.533

High

1227562

A16L1
Autophagy-related protein 16-1

1

18

High-throughput

0.514

High

410499

PRM2
Protamine-2

1

0

High-throughput

0.513

High

1411816

LLPH
Protein LLP homolog

1

0

High-throughput

0.513

High

191835

MAGB2
Melanoma-associated antigen B2

1

6

High-throughput

0.489

High

860026

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.489

High

1290051

PNM8A
Paraneoplastic antigen-like protein 8A

1

1

High-throughput

0.489

High

1433088

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.489

High

1450948

PURG
Purine-rich element-binding protein gamma

1

1

High-throughput

0.489

High

1450951

SRPK3
SRSF protein kinase 3

1

16

High-throughput

0.489

High

130799

TAF4
Transcription initiation factor TFIID subunit 4

1

7

High-throughput

0.479

High

140639

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

1

4

High-throughput

0.479

High

274779

DNJB6
DnaJ homolog subfamily B member 6

1

13

High-throughput

0.479

High

287823

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.479

High

290760

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.479

High

301238

RL1D1
Ribosomal L1 domain-containing protein 1

1

9

High-throughput

0.479

High

542673

TOP2A
DNA topoisomerase 2-alpha

1

4

High-throughput

0.479

High

589843

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

611993

RL35A
Large ribosomal subunit protein eL33

1

3

High-throughput

0.479

High

636152

CD11B
Cyclin-dependent kinase 11B

1

7

High-throughput

0.479

High

637758

FLNA
Filamin-A

1

8

High-throughput

0.479

High

658435

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

664820

CCND1
G1/S-specific cyclin-D1

1

5

Small-scale

0.479

High

696664

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

704993

RBL1
Retinoblastoma-like protein 1

1

1

High-throughput

0.479

High

769329

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

810417

RL3
Large ribosomal subunit protein uL3

1

5

High-throughput

0.479

High

831520

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

841478

RBM34
RNA-binding protein 34

1

7

High-throughput

0.479

High

854343

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.479

High

859091

RL27A
Large ribosomal subunit protein uL15

1

3

High-throughput

0.479

High

859475

RL5
Large ribosomal subunit protein uL18

1

4

High-throughput

0.479

High

860381

RS9
Small ribosomal subunit protein uS4

1

5

High-throughput

0.479

High

943321

RBM11
Splicing regulator RBM11

1

4

High-throughput

0.479

High

965276

WDR5
WD repeat-containing protein 5

1

16

Small-scale

0.479

High

972588

RS14
Small ribosomal subunit protein uS11

1

6

High-throughput

0.479

High

973606

RS11
Small ribosomal subunit protein uS17

1

4

High-throughput

0.479

High

977389

RS4X
Small ribosomal subunit protein eS4, X isoform

1

3

High-throughput

0.479

High

983071

RS25
Small ribosomal subunit protein eS25

1

2

High-throughput

0.479

High

985915

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.479

High

1004413

NOP14
Nucleolar protein 14

1

1

High-throughput

0.479

High

1039577

TOP2B
DNA topoisomerase 2-beta

1

4

High-throughput

0.479

High

1041861

CENPC
Centromere protein C

1

1

High-throughput

0.479

High

1043766

CEBPZ
CCAAT/enhancer-binding protein zeta

1

2

High-throughput

0.479

High

1065463

SSRP1
FACT complex subunit SSRP1

1

19

High-throughput

0.479

High

1100450

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

1105103

TCOF
Treacle protein

1

14

High-throughput

0.479

High

1140035

RRS1
Ribosome biogenesis regulatory protein homolog

1

1

High-throughput

0.479

High

1145399

RNPS1
RNA-binding protein with serine-rich domain 1

1

5

High-throughput

0.479

High

1148173

PUM3
Pumilio homolog 3

1

2

High-throughput

0.479

High

1152655

ELAV1
ELAV-like protein 1

1

2

High-throughput

0.479

High

1161707

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.479

High

1204639

BCORL
BCL-6 corepressor-like protein 1

1

2

High-throughput

0.479

High

1228283

ARID2
AT-rich interactive domain-containing protein 2

1

7

High-throughput

0.479

High

1228606

SPT2
Protein SPT2 homolog

1

5

High-throughput

0.479

High

1242500

NFRKB
Nuclear factor related to kappa-B-binding protein

1

5

High-throughput

0.479

High

1245509

CC137
Coiled-coil domain-containing protein 137

1

1

High-throughput

0.479

High

1276111

KANL1
KAT8 regulatory NSL complex subunit 1

1

3

High-throughput

0.479

High

1279913

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

8

High-throughput

0.479

High

1314713

SRRM1
Serine/arginine repetitive matrix protein 1

1

11

High-throughput

0.479

High

1332238

KRI1
Protein KRI1 homolog

1

3

High-throughput

0.479

High

1341154

WDR36
WD repeat-containing protein 36

1

19

High-throughput

0.479

High

1351486

BRX1
Ribosome biogenesis protein BRX1 homolog

1

5

High-throughput

0.479

High

1356043

NOC3L
Nucleolar complex protein 3 homolog

1

4

High-throughput

0.479

High

1361250

DNJC9
DnaJ homolog subfamily C member 9

1

14

High-throughput

0.479

High

1364277

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

High-throughput

0.479

High

1367405

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

1386601

OPTN
Optineurin

1

17

High-throughput

0.479

High

1399767

RBM14
RNA-binding protein 14

1

10

High-throughput

0.479

High

1400617

KI20B
Kinesin-like protein KIF20B

1

12

High-throughput

0.479

High

1403262

RSF1
Remodeling and spacing factor 1

1

20

High-throughput

0.479

High

1403515

MINT
Msx2-interacting protein

1

10

High-throughput

0.479

High

1407717

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.479

High

1411097

BUD13
BUD13 homolog

1

3

High-throughput

0.479

High

1411667

GPTC1
G patch domain-containing protein 1

1

1

High-throughput

0.479

High

1412264

NOL10
Nucleolar protein 10

1

1

High-throughput

0.479

High

1419706

GTPB4
GTP-binding protein 4

1

6

High-throughput

0.479

High

1428453

SENP6
Sentrin-specific protease 6

1

5

High-throughput

0.479

High

1434527

HEAT1
HEAT repeat-containing protein 1

1

3

High-throughput

0.479

High

1434928

CCD86
Coiled-coil domain-containing protein 86

1

1

High-throughput

0.479

High

1435073

NOL6
Nucleolar protein 6

1

1

High-throughput

0.479

High

1435608

RPF2
Ribosome production factor 2 homolog

1

1

High-throughput

0.479

High

1436266

NOL11
Nucleolar protein 11

1

1

High-throughput

0.479

High

1437836

CLSPN
Claspin

1

4

High-throughput

0.479

High

1438653

CBX8
Chromobox protein homolog 8

1

7

High-throughput

0.479

High

1438926

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.479

High

1448207

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

1450937

RBM28
RNA-binding protein 28

1

5

High-throughput

0.479

High

1450939

CDK12
Cyclin-dependent kinase 12

1

7

High-throughput

0.479

High

1450941

SENP1
Sentrin-specific protease 1

1

5

High-throughput

0.479

High

1450943

KANL3
KAT8 regulatory NSL complex subunit 3

1

2

High-throughput

0.479

High

1450947

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

17

High-throughput

0.479

High

1450949

YETS2
YEATS domain-containing protein 2

1

13

High-throughput

0.479

High

1450952

SRRM2
Serine/arginine repetitive matrix protein 2

1

16

High-throughput

0.479

High

1450955

SP16H
FACT complex subunit SPT16

1

4

High-throughput

0.479

High

1450956

NCOR2
Nuclear receptor corepressor 2

1

15

High-throughput

0.479

High

335920

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.458

High

1124136

NPAT
Protein NPAT

1

0

High-throughput

0.458

High

1200958

SGO2
Shugoshin 2

1

0

High-throughput

0.458

High

1239152

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.458

High

1240402

M18BP
Mis18-binding protein 1

1

0

High-throughput

0.458

High

1275506

TRM1L
tRNA

1

0

High-throughput

0.458

High

1295312

P66A
Transcriptional repressor p66-alpha

1

0

High-throughput

0.458

High

1338182

PPHLN
Periphilin-1

1

0

High-throughput

0.458

High

1339888

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.458

High

1416350

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.458

High

1428481

REXO4
RNA exonuclease 4

1

0

High-throughput

0.458

High

1450944

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.458

High

1450954

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.458

High

430424

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

1212380

GPTC4
G patch domain-containing protein 4

1

3

High-throughput

0.445

High

106731

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

272498

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.437

High

346407

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.437

High

391665

FRIH
Ferritin heavy chain

1

3

High-throughput

0.437

High

409102

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.437

High

425963

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

11

High-throughput

0.437

High

504988

H2AB2
Histone H2A-Bbd type 2/3

1

6

High-throughput

0.437

High

587823

DESP
Desmoplakin

1

14

High-throughput

0.437

High

615449

SON
Protein SON

1

2

High-throughput

0.437

High

749148

RL9
Large ribosomal subunit protein uL6

1

2

High-throughput

0.437

High

923716

SMTN
Smoothelin

1

7

High-throughput

0.437

High

984306

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

16

High-throughput

0.437

High

1219756

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.437

High

1336374

Z280C
Zinc finger protein 280C

1

2

High-throughput

0.437

High

1402256

WRIP1
ATPase WRNIP1

1

2

High-throughput

0.437

High

1406063

PHB2
Prohibitin-2

1

3

High-throughput

0.437

High

1428387

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.437

High

1438809

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

11

High-throughput

0.437

High

1450946

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

10

High-throughput

0.437

High

1450950

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

69984

A8KAG1
G patch domain-containing protein 4

1

3

High-throughput

0.407

High

1448896

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.279

Low

1414475

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

1438915

ZN532
Zinc finger protein 532

1

0

High-throughput

0.249

Low

1450953

RRP15
RRP15-like protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025