HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: KANK2 (Q63ZY3)
KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25) (Matrix-remodeling-associated protein 3) (SRC-1-interacting protein) (SIP) (SRC-interacting protein) (SRC1-interacting protein)
Gene: KANK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30979931
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 851
+	Hs
		1044264 DYR1A_HUMAN (1-763): 0: 613: 100.00		KDIS_HUMAN (659-844): 1.07e-37: 155: 28.04
+	Hs
		1043935 DYR1A_HUMAN (1-763): 0: 613: 100.00		ANKH1_HUMAN (349-849): 1.99e-26: 119: 13.92
+	Hs
		1044215 DYR1A_HUMAN (1-763): 0: 613: 100.00		RAI14_HUMAN (710-831): 8.96e-21: 100: 27.05
+	Hs
		257676 DYRK2_HUMAN (46-549): 5.03e-120: 375: 33.53		ANR17_HUMAN (553-836): 3.23e-37: 154: 20.42
+	Hs
		647851 MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72		DAPK1_HUMAN (658-791): 1.53e-24: 112: 31.34
+	Hs
		681849 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		KANK1_HUMAN (732-850): 2.2e-19: 95.9: 23.81
+	Hs
		625621 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		RAI14_HUMAN (710-831): 8.96e-21: 100: 27.05