HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: LZTS1 (Q9Y250)
Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1)
Gene: LZTS1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	30773093, 36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 763 Hs			1 596
+	Hs
		1044103 DYR1A_HUMAN (1-763): 0: 613: 100.00		LZTS2_HUMAN (1-596): 1.2e-37: 150: 34.66
+	Hs
		230539 DYR1A_HUMAN (1-763): 0: 613: 100.00		LZTS3_HUMAN (99-596): 3.57e-36: 145: 35.68
+	Hs
		1044003 DYR1A_HUMAN (1-763): 0: 613: 100.00		TSC1_HUMAN (7-587): 1.97e-34: 141: 11.77
+	Mm
		1142388 DYR1A_MOUSE (1-763): 0: 610: 99.21		TSC1_MOUSE (12-571): 6.3e-33: 137: 12.96
+	Hs
		528372 DYR1A_HUMAN (1-763): 0: 613: 100.00		MYH6_HUMAN (163-595): 8.39e-14: 77.3: 12.70
+	Hs
		725159 DYR1A_HUMAN (1-763): 0: 613: 100.00		MYH10_HUMAN (140-534): 1.83e-10: 66.5: 11.62
+	Hs
		728476 DYR1A_HUMAN (1-763): 0: 613: 100.00		MYH11_HUMAN (218-594): 5.2e-10: 65: 13.22
+	Hs
		415112 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		LZTS1_HUMAN (1-596): 1.46e-59: 210: 100.00
+	Hs
		1310236 DYR1B_HUMAN (57-600): 2.33e-137: 421: 68.13		LZTS2_HUMAN (1-596): 1.2e-37: 150: 34.66
+	Hs
		230558 DYR1B_HUMAN (57-600): 2.33e-137: 421: 68.13		LZTS3_HUMAN (99-596): 3.57e-36: 145: 35.68
+	Hs
		1310137 HIPK2_HUMAN (3-763): 2.24e-117: 383: 22.62		LZTS2_HUMAN (1-596): 1.2e-37: 150: 34.66
+	Hs
		1268586 DYRK2_HUMAN (46-549): 5.03e-120: 375: 33.53		LZTS2_HUMAN (1-596): 1.2e-37: 150: 34.66
+	Hs
		415012 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		TSC1_HUMAN (7-587): 1.97e-34: 141: 11.77
+	Hs
		647995 MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72		MTCL1_HUMAN (8-570): 1.12e-25: 115: 11.74
+	Hs
		681956 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		TSC1_HUMAN (7-587): 1.97e-34: 141: 11.77
+	Mm
		682126 AKT1_MOUSE (38-466): 2.26e-117: 364: 19.42		TSC1_MOUSE (12-571): 6.3e-33: 137: 12.96
+	Hs
		681840 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		DCTN1_HUMAN (182-587): 6.97e-24: 108: 13.40
+	Hs
		414713 CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57		DESP_HUMAN (275-570): 1.97e-10: 66.5: 16.23
+	Hs
		551616 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		DESP_HUMAN (275-570): 1.97e-10: 66.5: 16.23
+	Hs
		681696 AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42		MYH9_HUMAN (154-534): 4.65e-10: 64.9: 12.04