Protein: RBX1
RING-box protein HRT1 (RING-box protein 1) (E3 ubiquitin-protein ligase complex SCF subunit HRT1) (High level expression reduces Ty3 transposition protein 1) (Regulator of cullins protein 1)

Gene: RBX1, HRT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 189
UniProt ID: Q08273

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000409 - regulation of transcription by galactose
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

574821

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

22

20

Small-scale

0.990

High

1062881

CDC53
Cell division control protein 53

16

20

Small-scale

0.986

High

918194

CUL3
Cullin-3

4

20

Small-scale

0.883

High

917923

YBP2
YAP1-binding protein 2

3

0

High-throughput

0.782

High

585737

UBC4
Ubiquitin-conjugating enzyme E2 4

2

20

Small-scale

0.778

High

585761

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

2

20

Small-scale

0.778

High

912394

UBC12
NEDD8-conjugating enzyme UBC12

2

20

Small-scale

0.778

High

1062888

DCN1
Defective in cullin neddylation protein 1

2

9

Small-scale

0.778

High

460746

CDC4
Cell division control protein 4

8

11

Small-scale

0.750

High

910797

SKP1
Suppressor of kinetochore protein 1

6

3

Small-scale

0.727

High

864615

CUL8
Cullin-8

4

20

Small-scale

0.703

High

666713

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

4

6

Small-scale

0.690

High

826366

YIA1
Ankyrin repeat-containing protein YIL001W

4

17

High-throughput

0.677

High

1062889

APC2
Anaphase-promoting complex subunit 2

1

20

Small-scale

0.656

High

1054350

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

4

0

Small-scale

0.652

High

809297

MET30
F-box protein MET30

3

13

Small-scale

0.650

High

509743

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

7

High-throughput

0.618

High

574612

YAK1
Dual specificity protein kinase YAK1

2

4

High-throughput

0.590

High

1062886

HRT3
F-box protein HRT3

2

1

Small-scale

0.585

High

386887

TBB
Tubulin beta chain

2

7

High-throughput

0.584

High

676419

MAS5
Mitochondrial protein import protein MAS5

2

2

High-throughput

0.584

High

1044297

RUB1
NEDD8-like protein RUB1

1

5

High-throughput

0.575

High

1053147

UCC1
F-box protein UCC1

2

0

Small-scale

0.560

High

150101

YA11B
Truncated transposon Ty1-A Gag-Pol polyprotein

1

1

High-throughput

0.536

High

534317

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.536

High

559661

GAL3
Protein GAL3

1

1

High-throughput

0.536

High

598925

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.536

High

623963

MYO2
Myosin-2

1

10

High-throughput

0.536

High

722319

XPO1
Exportin-1

1

1

High-throughput

0.536

High

739518

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

5

High-throughput

0.536

High

803172

ECM29
Proteasome component ECM29

1

6

High-throughput

0.536

High

803703

RPN1
26S proteasome regulatory subunit RPN1

1

4

High-throughput

0.536

High

863061

GUF1
Translation factor GUF1, mitochondrial

1

4

High-throughput

0.536

High

868455

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

2

High-throughput

0.536

High

1060414

RIX7
Ribosome biogenesis ATPase RIX7

1

8

High-throughput

0.536

High

1062880

RPN8
26S proteasome regulatory subunit RPN8

1

9

High-throughput

0.536

High

1062882

MDN1
Midasin

1

13

High-throughput

0.536

High

798636

SAF1
SCF-associated factor 1

1

0

High-throughput

0.530

High

924033

ELOA1
Elongin-A

2

0

Small-scale

0.528

High

813327

RRF2M
Ribosome-releasing factor 2, mitochondrial

2

2

High-throughput

0.516

High

1062893

HSH49
Protein HSH49

1

3

High-throughput

0.515

High

452760

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.513

High

657130

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.513

High

679007

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.513

High

828325

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

1026974

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.513

High

1056519

UBX5
UBX domain-containing protein 5

1

2

High-throughput

0.508

High

864013

DAS1
F-box protein DAS1

1

1

Small-scale

0.501

High

1042302

TFB3
RNA polymerase II transcription factor B subunit 3

1

1

Small-scale

0.501

High

1044285

YD131
F-box protein YDR131C

1

1

Small-scale

0.501

High

394959

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.500

High

408361

GAL1
Galactokinase

1

1

High-throughput

0.500

High

453829

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.500

High

486335

TBA1
Tubulin alpha-1 chain

1

9

High-throughput

0.500

High

486521

TBA3
Tubulin alpha-3 chain

1

9

High-throughput

0.500

High

531415

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

592542

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.500

High

599084

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.500

High

680119

CDC48
Cell division control protein 48

1

8

High-throughput

0.500

High

740230

RPN2
26S proteasome regulatory subunit RPN2

1

2

High-throughput

0.500

High

763503

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.500

High

817970

IMB4
Importin subunit beta-4

1

9

High-throughput

0.500

High

865091

TCPQ
T-complex protein 1 subunit theta

1

4

High-throughput

0.500

High

948675

ACT
Actin

1

7

High-throughput

0.500

High

624817

PMA2
Plasma membrane ATPase 2

1

3

High-throughput

0.489

High

755185

GCN1
eIF-2-alpha kinase activator GCN1

1

4

High-throughput

0.489

High

864758

BBC1
Myosin tail region-interacting protein MTI1

1

5

High-throughput

0.489

High

843220

SKP2
F-box protein SKP2

1

0

Small-scale

0.480

High

1046841

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.480

High

1052935

MDM30
Mitochondrial distribution and morphology protein 30

1

0

Small-scale

0.480

High

1056366

YD306
F-box protein YDR306C

1

0

Small-scale

0.480

High

1062879

DIA2
Protein DIA2

1

0

Small-scale

0.480

High

450654

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.479

High

590740

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

836928

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.479

High

580179

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

708384

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

741157

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

4

High-throughput

0.479

High

1062884

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

1062890

CMR1
DNA damage-binding protein CMR1

1

8

High-throughput

0.479

High

1062891

SMC6
Structural maintenance of chromosomes protein 6

1

9

High-throughput

0.479

High

721422

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.458

High

826895

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

1042683

SLD5
DNA replication complex GINS protein SLD5

1

0

Small-scale

0.458

High

1053992

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

458967

LYS2
L-2-aminoadipate reductase

1

2

High-throughput

0.457

High

757639

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.457

High

777132

BDF1
Bromodomain-containing factor 1

1

2

High-throughput

0.457

High

794261

YPT10
GTP-binding protein YPT10

1

1

High-throughput

0.457

High

823200

RAD26
DNA repair and recombination protein RAD26

1

2

High-throughput

0.457

High

864536

MTR4
ATP-dependent RNA helicase DOB1

1

5

High-throughput

0.457

High

924404

RIA1
Ribosome assembly protein 1

1

3

High-throughput

0.457

High

367134

ATPB
ATP synthase subunit beta, mitochondrial

1

5

High-throughput

0.457

High

405151

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

452980

ATPA
ATP synthase subunit alpha, mitochondrial

1

5

High-throughput

0.457

High

621411

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.457

High

926286

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

1

High-throughput

0.457

High

393445

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.445

High

481790

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

548926

SCH9
Serine/threonine-protein kinase SCH9

1

4

High-throughput

0.445

High

760368

BMH2
Protein BMH2

1

4

High-throughput

0.445

High

816445

HSP7E
Heat shock protein SSC3, mitochondrial

1

12

High-throughput

0.445

High

818701

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

1

High-throughput

0.445

High

819985

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

1040688

ELOC
Elongin-C

1

2

Small-scale

0.445

High

416573

HXKB
Hexokinase-2

1

0

High-throughput

0.438

High

448233

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.438

High

454355

PHO2
Regulatory protein PHO2

1

0

High-throughput

0.438

High

542734

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.438

High

638119

OSM1
Fumarate reductase 2

1

0

High-throughput

0.438

High

776339

MRP8
Uncharacterized protein MRP8

1

0

High-throughput

0.438

High

780921

FRMSR
Free methionine-R-sulfoxide reductase

1

0

High-throughput

0.438

High

794146

ERT1
Transcription activator of gluconeogenesis ERT1

1

0

High-throughput

0.438

High

816073

ACA1
ATF/CREB activator 1

1

0

High-throughput

0.438

High

845911

NSE4
Non-structural maintenance of chromosome element 4

1

0

High-throughput

0.438

High

849931

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.438

High

850989

MHP1
MAP-homologous protein 1

1

0

High-throughput

0.438

High

864974

NOP9
Nucleolar protein 9

1

0

High-throughput

0.438

High

874271

CLA4
Serine/threonine-protein kinase CLA4

1

0

High-throughput

0.438

High

1030931

BLH1
Cysteine proteinase 1, mitochondrial

1

0

High-throughput

0.438

High

1035378

YKZ1
Uncharacterized protein YKR011C

1

0

High-throughput

0.438

High

1046290

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.438

High

1046466

MIX14
Mitochondrial intermembrane space cysteine motif-containing protein MIX14

1

0

High-throughput

0.438

High

1046550

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.438

High

1048264

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.438

High

1056410

CENPO
Inner kinetochore subunit MCM21

1

0

High-throughput

0.438

High

1056544

CDC73
Cell division control protein 73

1

0

High-throughput

0.438

High

1062895

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.438

High

150313

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.426

High

510982

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.426

High

797224

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.426

High

805738

NDT80
Meiosis-specific transcription factor NDT80

1

0

High-throughput

0.426

High

813312

FHP
Flavohemoprotein

1

0

High-throughput

0.426

High

1028012

STP1
Transcription factor STP1

1

0

High-throughput

0.426

High

1046480

BUD22
Bud site selection protein 22

1

0

High-throughput

0.426

High

1055299

YL352
F-box protein YLR352W

1

0

High-throughput

0.426

High

1060317

ISA1
Iron-sulfur assembly protein 1

1

0

High-throughput

0.426

High

1062887

CSN10
COP9 signalosome complex subunit 10

1

0

High-throughput

0.426

High

581817

SYDM
Aspartate--tRNA ligase, mitochondrial

1

1

High-throughput

0.417

High

803192

WSC4
Cell wall integrity and stress response component 4

1

5

High-throughput

0.417

High

812963

MST28
Multicopy suppressor of SEC21 protein 28

1

1

High-throughput

0.417

High

824623

CSS1
Secreted protein CSS1

1

5

High-throughput

0.417

High

852618

ROK1
ATP-dependent RNA helicase ROK1

1

4

High-throughput

0.417

High

917898

MRH4
ATP-dependent RNA helicase MRH4, mitochondrial

1

4

High-throughput

0.417

High

923729

COS1
Protein COS1

1

1

High-throughput

0.417

High

1046267

UTP15
U3 small nucleolar RNA-associated protein 15

1

3

High-throughput

0.417

High

1062885

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

1

High-throughput

0.417

High

367409

CISY1
Citrate synthase, mitochondrial

1

2

High-throughput

0.407

High

1062892

LAG2
Cullin-associated NEDD8-dissociated protein 1 homolog

2

0

Small-scale

0.328

High

812843

ACON2
Homocitrate dehydratase, mitochondrial

2

0

High-throughput

0.307

High

1062764

CRT10
Protein CRT10

2

0

Small-scale

0.298

High

705793

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

0

High-throughput

0.279

Low

796549

ECM33
Cell wall protein ECM33

1

0

High-throughput

0.279

Low

800648

YGP1
Protein YGP1

1

0

High-throughput

0.279

Low

836111

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.279

Low

1060646

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.279

Low

763783

CBF3C
Centromere DNA-binding protein complex CBF3 subunit C

1

0

Small-scale

0.261

Low

812831

RCY1
Recyclin-1

1

0

Small-scale

0.261

Low

408595

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

484800

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

619390

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

673535

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.261

Low

428027

PLMT
Phosphatidyl-N-methylethanolamine N-methyltransferase

1

0

High-throughput

0.238

Low

648014

RM20
Large ribosomal subunit protein mL58

1

0

High-throughput

0.238

Low

705113

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.238

Low

740121

SCM4
Protein SCM4

1

0

High-throughput

0.238

Low

740378

SNQ2
Protein SNQ2

1

0

High-throughput

0.238

Low

740780

STE14
Protein-S-isoprenylcysteine O-methyltransferase

1

0

High-throughput

0.238

Low

746078

SEC6
Exocyst complex component SEC6

1

0

High-throughput

0.238

Low

781086

TCD2
tRNA threonylcarbamoyladenosine dehydratase 2

1

0

High-throughput

0.238

Low

795677

RRT1
Regulator of rDNA transcription protein 1

1

0

High-throughput

0.238

Low

795689

YBE4
Uncharacterized protein YBL044W

1

0

High-throughput

0.238

Low

797826

CS111
F-box protein COS111

1

0

High-throughput

0.238

Low

805144

YHP5
Putative uncharacterized protein YHR095W

1

0

High-throughput

0.238

Low

805767

YHT0
Uncharacterized protein YHR130C

1

0

High-throughput

0.238

Low

818676

YE17
Uncharacterized protein YER187W

1

0

High-throughput

0.238

Low

866173

ENT3
Epsin-3

1

0

High-throughput

0.238

Low

916785

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.238

Low

1038086

SMA1
Spore membrane assembly protein 1

1

0

High-throughput

0.238

Low

1039931

RT51
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.238

Low

1059584

SNA4
Protein SNA4

1

0

High-throughput

0.238

Low

1062883

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.238

Low

1062894

AP2M
AP-2 complex subunit mu

1

0

High-throughput

0.238

Low

376349

YPT1
GTP-binding protein YPT1

1

0

High-throughput

0.232

Low

480003

PRTB
Cerevisin

1

0

High-throughput

0.232

Low

796062

DSF2
Protein DSF2

1

0

High-throughput

0.232

Low

803221

NPR3
Nitrogen permease regulator 3

1

0

High-throughput

0.232

Low

1053922

BOP2
Protein BOP2

1

0

High-throughput

0.232

Low

1059561

ATG20
Autophagy-related protein 20

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025