HitPredict

Interactor 1: PTC1 (Q13635)
Protein patched homolog 1 (PTC) (PTC1)
Gene: PTCH1

Interactor 2: SMO (Q99835)
Protein smoothened (Protein Gx)
Gene: SMO

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 0.60 0.615

The method score is based on:

Property Details
Experiments 9811851, 11278759
Identification Methods affinity chromatography technology, confocal microscopy, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001701 - in utero embryonic development
GO:0005113 - patched binding
GO:0005886 - plasma membrane
GO:0007224 - smoothened signaling pathway
and 9 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 1447
Hs

1 787
+ Hs
+ Dm
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024