HitPredict

Interactor 1: CAC1S (Q13698)
Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1)
Gene: CACNA1S

Interactor 2: TNKS2 (Q9H2K2)
Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)
Gene: TNKS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	12080061, 22153077
Identification Methods	two hybrid, fluorescence polarization spectroscopy
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0046872 - metal ion binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1873 Hs			1 1166
+	Hs
		310051 CAC1S_HUMAN (1-1873): 0: 1817: 100.00		TNKS1_HUMAN (2-335): 1.11e-73: 270: 35.95
+	Hs
		1021401 SCN5A_HUMAN (334-586): 2.34e-20: 101: 16.73		ANK3_HUMAN (836-1140): 9.74e-22: 104: 9.18
+	Rn
		251017 SCN8A_RAT (1102-1404): 1.1e-21: 105: 16.09		ANK3_RAT (836-1140): 2.14e-20: 100: 9.88
+	Rn
		251019 SCN2A_RAT (1103-1409): 1.11e-19: 98.8: 16.04		ANK3_RAT (836-1140): 2.14e-20: 100: 9.88
+	Rn
		251018 SCN1A_RAT (1103-1289): 4.22e-18: 93.8: 22.51		ANK3_RAT (836-1140): 2.14e-20: 100: 9.88