Protein: NLE1
Ribosome assembly protein 4 (Notchless protein homolog 1) (Ribosome biogenesis factor RSA4)

Gene: NLE1, RSA4
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: P25382

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0005730 - nucleolus
GO:0110136 - protein-RNA complex remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

673579

PESC
Pescadillo homolog

7

2

Small-scale

0.951

High

673583

IPI3
Pre-rRNA-processing protein IPI3

3

18

Small-scale

0.855

High

673547

SPB4
ATP-dependent rRNA helicase SPB4

3

20

High-throughput

0.827

High

673575

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

7

High-throughput

0.789

High

673588

ARX1
Probable metalloprotease ARX1

12

2

Small-scale

0.755

High

673545

NLE1
Ribosome assembly protein 4

2

16

Small-scale

0.754

High

673554

DRS1
ATP-dependent RNA helicase DRS1

2

20

Small-scale

0.754

High

673568

NSA2
Ribosome biogenesis protein NSA2

8

2

Small-scale

0.750

High

673598

MDN1
Midasin

7

19

Small-scale

0.749

High

673567

NUG1
Nuclear GTP-binding protein NUG1

8

7

Small-scale

0.744

High

673581

NOG2
Nucleolar GTP-binding protein 2

8

7

Small-scale

0.744

High

673564

RIX1
Pre-rRNA-processing protein RIX1

12

0

Small-scale

0.725

High

673580

SDA1
Protein SDA1

5

1

Small-scale

0.709

High

673555

MRT4
Ribosome assembly factor MRT4

5

9

Small-scale

0.702

High

673599

NOP53
Ribosome biogenesis protein NOP53

5

2

Small-scale

0.699

High

673586

NOG1
Nucleolar GTP-binding protein 1

4

5

Small-scale

0.676

High

673582

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

19

High-throughput

0.665

High

673601

IF6
Eukaryotic translation initiation factor 6

4

0

Small-scale

0.648

High

673557

RPF2
Ribosome biogenesis protein RPF2

3

1

Small-scale

0.640

High

673559

CIC1
Proteasome-interacting protein CIC1

3

6

Small-scale

0.640

High

673561

IPI1
Pre-rRNA-processing protein IPI1

3

2

Small-scale

0.640

High

673571

RLP7
Ribosome biogenesis protein RLP7

3

8

Small-scale

0.640

High

673593

RLP24
Ribosome biogenesis protein RLP24

3

3

Small-scale

0.640

High

673546

SPB1
27S pre-rRNA

1

6

High-throughput

0.618

High

673587

HAS1
ATP-dependent RNA helicase HAS1

1

20

Small-scale

0.618

High

673591

ERB1
Ribosome biogenesis protein ERB1

1

17

Small-scale

0.618

High

673578

CGR1
rRNA-processing protein CGR1

3

0

Small-scale

0.606

High

569915

RL3
Large ribosomal subunit protein uL3

2

7

Small-scale

0.584

High

673577

LSG1
Large subunit GTPase 1

2

7

Small-scale

0.584

High

673584

NOP15
Ribosome biogenesis protein 15

2

16

Small-scale

0.584

High

673597

RRS1
Regulator of ribosome biosynthesis

2

1

Small-scale

0.584

High

673553

AFG2
ATPase family gene 2 protein

2

12

Small-scale

0.533

High

673562

YHS2
MIP18 family protein YHR122W

1

4

High-throughput

0.528

High

673590

UTP14
U3 small nucleolar RNA-associated protein 14

1

11

High-throughput

0.515

High

673569

SSB2
Ribosome-associated molecular chaperone SSB2

2

16

High-throughput

0.504

High

673549

SBA1
Co-chaperone protein SBA1

1

3

Small-scale

0.481

High

409954

RL25
Large ribosomal subunit protein uL23

1

4

Small-scale

0.479

High

427150

RLA0
Large ribosomal subunit protein uL10

1

9

Small-scale

0.479

High

673548

RL5
Large ribosomal subunit protein uL18

1

6

Small-scale

0.479

High

673572

NOP2
25S rRNA

1

4

High-throughput

0.479

High

673573

UTP10
U3 small nucleolar RNA-associated protein 10

1

3

High-throughput

0.479

High

673595

NOP12
Nucleolar protein 12

1

17

High-throughput

0.479

High

673600

RRP6
Exosome complex exonuclease RRP6

1

5

High-throughput

0.479

High

673558

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

673560

SSF1
Ribosome biogenesis protein SSF1

1

0

High-throughput

0.458

High

673570

BMT5
25S rRNA

1

0

High-throughput

0.458

High

673576

NSA1
Ribosome biogenesis protein NSA1

1

0

Small-scale

0.458

High

673589

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

448649

SNF1
Carbon catabolite-derepressing protein kinase

1

2

High-throughput

0.457

High

602334

PHO85
Cyclin-dependent protein kinase PHO85

1

8

High-throughput

0.457

High

673565

AURK
Aurora kinase

1

11

High-throughput

0.457

High

513638

RL2A
Large ribosomal subunit protein uL2A

1

5

High-throughput

0.437

High

515214

RL35A
Large ribosomal subunit protein uL29A

1

1

Small-scale

0.437

High

594216

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.437

High

673550

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

673551

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.437

High

673552

NGG1
SAGA complex subunit NGG1

1

1

High-throughput

0.437

High

673566

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

673585

NOP3
Serine/arginine

1

20

High-throughput

0.437

High

673592

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

673596

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.437

High

394276

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

453442

PYR1
Multifunctional protein URA2

1

7

High-throughput

0.407

High

510236

HSP77
Import motor subunit, mitochondrial

1

19

High-throughput

0.407

High

531618

RL4A
Large ribosomal subunit protein uL4A

1

7

High-throughput

0.407

High

673594

BUD20
Bud site selection protein 20

5

0

Small-scale

0.374

High

673574

ALB1
Ribosome biogenesis protein ALB1

4

0

Small-scale

0.358

High

673563

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.249

Low

673556

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025