HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	3027087, 11441066
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CH~EF-hand_7, CH~EFhand_Ca_insen, CH~Spectrin, SH3_10~Spectrin
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045296 - cadherin binding GO:0051015 - actin filament binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2472 Hs			1 4684
+	Hs
		360644 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		PLEC_HUMAN (1-4684): 0: 1783: 100.00
+	Hs
		506818 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SPTB1_HUMAN (151-2274): 6.68e-124: 442: 17.12
+	Rn
		555261 SPTN1_RAT (1-2472): 0: 713: 98.58		ACTN1_RAT (153-876): 3.38e-112: 383: 24.07
+	Dm
		527092 SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92		SPTCB_DROME (151-2288): 1.11e-120: 432: 17.73
+	Hs
		360607 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		SPTB1_HUMAN (151-2274): 6.68e-124: 442: 17.12
+	Hs
		164614 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SPTN2_HUMAN (1390-3166): 2.85e-25: 118: 12.24
+	Hs
		963320 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53
+	Rn
		555258 SPTN1_RAT (1-2472): 0: 713: 98.58		Q6XD99_RAT (1531-3190): 1.96e-15: 86.6: 9.24
+	Hs
		1045513 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SPTN4_HUMAN (1394-3173): 6.68e-13: 78.1: 10.95
+	Dm
		527098 SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92		Q7KV70_DROME (995-2857): 6.55e-22: 108: 13.16
+	Ce
		103420 G4S034_CAEEL (4-2472): 4.08e-165: 570: 57.91		G5EG85_CAEEL (1106-2831): 9.89e-25: 117: 10.34
+	Mm
		434793 SPTA1_MOUSE (1-2472): 2.17e-161: 558: 54.20		DMD_MOUSE (1215-3224): 1.33e-25: 120: 9.43
+	Dm
		54294 SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92		A1Z9J2_DROME (1999-3318): 6.56e-10: 68.5: 9.56
+	Hs
		360638 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53
+	Ce
		103418 G4S034_CAEEL (4-2472): 4.08e-165: 570: 57.91		G5ECP9_CAEEL (1550-2705): 1.17e-11: 74.3: 10.92
+	Mm
		93541 SPTA1_MOUSE (1-2472): 2.17e-161: 558: 54.20		DESP_MOUSE (351-883): 3.06e-11: 72.7: 8.07
+	Hs
		360664 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		SPTN4_HUMAN (1394-3173): 6.68e-13: 78.1: 10.95
+	Hs
		164603 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53
+	Hs
		963291 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53