Protein: NFAT5
Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP)

Gene: NFAT5
Organism: Homo sapiens
Interactions: 51
UniProt ID: O94916

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

321946

NFAT5
Nuclear factor of activated T-cells 5

1

19

Small-scale

0.724

High

190033

FOXP2
Forkhead box protein P2

1

17

Small-scale

0.618

High

321948

FOS
Protein c-Fos

1

20

Small-scale

0.618

High

321951

JUN
Transcription factor Jun

1

20

Small-scale

0.618

High

321959

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.618

High

321970

TF65
Transcription factor p65

1

19

Small-scale

0.618

High

321980

FOXP4
Forkhead box protein P4

1

17

Small-scale

0.618

High

321987

FOXP1
Forkhead box protein P1

1

17

Small-scale

0.618

High

321978

NF2L2
Nuclear factor erythroid 2-related factor 2

1

19

Small-scale

0.592

High

321949

TNFA
Tumor necrosis factor

2

15

Small-scale

0.584

High

321966

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

3

Small-scale

0.554

High

321947

ABL1
Tyrosine-protein kinase ABL1

1

3

Small-scale

0.536

High

321965

EPHA3
Ephrin type-A receptor 3

1

4

High-throughput

0.536

High

321971

ATM
Serine-protein kinase ATM

1

9

Small-scale

0.536

High

321973

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

321988

DDX21
Nucleolar RNA helicase 2

1

9

High-throughput

0.536

High

321960

DDX5
Probable ATP-dependent RNA helicase DDX5

1

5

Small-scale

0.515

High

321972

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.481

High

169365

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

4

Small-scale

0.479

High

296405

STAM2
Signal transducing adapter molecule 2

1

7

Small-scale

0.479

High

317120

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

5

Small-scale

0.479

High

321952

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

321953

PARP1
Poly [ADP-ribose] polymerase 1

1

7

Small-scale

0.479

High

321954

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

321957

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

321958

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

6

Small-scale

0.479

High

321961

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.479

High

321962

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

321964

S10A4
Protein S100-A4

1

2

Small-scale

0.479

High

321968

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

321974

HLTF
Helicase-like transcription factor

1

16

Small-scale

0.479

High

321975

IMB1
Importin subunit beta-1

1

5

Small-scale

0.479

High

321976

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

20

Small-scale

0.479

High

321977

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

Small-scale

0.479

High

321979

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

321981

WDR48
WD repeat-containing protein 48

1

9

Small-scale

0.479

High

321983

RND1
Rho-related GTP-binding protein Rho6

1

1

High-throughput

0.479

High

321984

STAM1
Signal transducing adapter molecule 1

1

5

Small-scale

0.479

High

321985

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

Small-scale

0.479

High

321986

CIC
Protein capicua homolog

1

14

High-throughput

0.479

High

321989

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

321990

TRAF6
TNF receptor-associated factor 6

1

6

Small-scale

0.479

High

321963

CP3A7
Cytochrome P450 3A7

1

2

Small-scale

0.470

High

321956

ALDR
Aldo-keto reductase family 1 member B1

1

0

Small-scale

0.458

High

321982

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

247065

TBCD4
TBC1 domain family member 4

1

1

Small-scale

0.457

High

321967

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.445

High

321950

CP2E1
Cytochrome P450 2E1

1

1

Small-scale

0.437

High

321955

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

Small-scale

0.437

High

321969

SC5A3
Sodium/myo-inositol cotransporter

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025