HitPredict

Interactor 1: LE418 (G5EBZ4)
Protein let-418 (Lethal protein 418)
Gene: let-418

Interactor 2: MES2 (O17514)
Histone-lysine N-methyltransferase mes-2 (EC 2.1.1.356) (E(z) homolog) (Maternal-effect sterile protein 2)
Gene: mes-2

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27651832
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1829 Ce			1 773
+	Ce
		184558 CHD3_CAEEL (1-1803): 0: 1594: 67.34		MES2_CAEEL (1-773): 0: 1188: 100.00
+	Hs
		1059880 CHD4_HUMAN (9-1712): 0: 1492: 46.59		EHMT1_HUMAN (475-772): 3.71e-83: 290: 21.15
+	Hs
		1059797 CHD4_HUMAN (9-1712): 0: 1492: 46.59		EHMT2_HUMAN (437-771): 1.98e-79: 279: 20.86
+	Hs
		1059639 CHD4_HUMAN (9-1712): 0: 1492: 46.59		EZH2_HUMAN (441-746): 5.02e-80: 273: 35.37
+	Hs
		203687 CHD4_HUMAN (9-1712): 0: 1492: 46.59		SUV91_HUMAN (433-763): 3.3e-81: 267: 18.96
+	Mm
		1125396 Q5DTP7_MOUSE (9-1702): 0: 1462: 46.11		Q6AXH7_MOUSE (441-746): 2.58e-79: 271: 35.37
+	Hs
		1018505 CHD3_HUMAN (14-1721): 0: 1434: 39.21		EZH2_HUMAN (441-746): 5.02e-80: 273: 35.37
+	Hs
		331813 CHD4_HUMAN (9-1712): 0: 1492: 46.59		NSD2_HUMAN (567-772): 6.74e-52: 198: 24.06
+	Hs
		165677 CHD4_HUMAN (9-1712): 0: 1492: 46.59		SET1A_HUMAN (603-760): 1.65e-51: 197: 30.63
+	Hs
		975252 CHD4_HUMAN (9-1712): 0: 1492: 46.59		KMT2A_HUMAN (613-760): 1.93e-49: 191: 28.86
+	Hs
		975235 CHD3_HUMAN (14-1721): 0: 1434: 39.21		KMT2A_HUMAN (613-760): 1.93e-49: 191: 28.86
+	Hs
		1080145 CHD6_HUMAN (47-1554): 0: 781: 24.38		EZH2_HUMAN (441-746): 5.02e-80: 273: 35.37
+	Hs
		658681 SMCA1_HUMAN (483-1409): 0: 767: 29.22		EZH2_HUMAN (441-746): 5.02e-80: 273: 35.37
+	Hs
		151444 CHD1_HUMAN (373-1410): 0: 757: 31.74		EHMT2_HUMAN (437-771): 1.98e-79: 279: 20.86
+	Hs
		229411 SMCA5_HUMAN (470-1409): 0: 762: 29.08		EZH2_HUMAN (441-746): 5.02e-80: 273: 35.37
+	Hs
		151417 CHD1_HUMAN (373-1410): 0: 757: 31.74		EZH2_HUMAN (441-746): 5.02e-80: 273: 35.37
+	Hs
		1080420 CHD7_HUMAN (389-1554): 0: 751: 28.43		EZH2_HUMAN (441-746): 5.02e-80: 273: 35.37
+	Hs
		165631 SMCA1_HUMAN (483-1409): 0: 767: 29.22		SET1A_HUMAN (603-760): 1.65e-51: 197: 30.63
+	Hs
		229270 SMCA5_HUMAN (470-1409): 0: 762: 29.08		NSD2_HUMAN (567-772): 6.74e-52: 198: 24.06
+	Hs
		165721 CHD8_HUMAN (118-1554): 0: 748: 24.78		SET1A_HUMAN (603-760): 1.65e-51: 197: 30.63