Protein: IQGA2
Ras GTPase-activating-like protein IQGAP2

Gene: IQGA2, IQGAP2
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q13576

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005095 - GTPase inhibitor activity
GO:0005096 - GTPase activator activity
GO:0005516 - calmodulin binding
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955140

CDC42
Cell division control protein 42 homolog

7

20

Small-scale

0.963

High

988345

RAC1
Ras-related C3 botulinum toxin substrate 1

5

20

Small-scale

0.931

High

1111483

CAB45
45 kDa calcium-binding protein

3

20

High-throughput

0.861

High

953431

RAC3
Ras-related C3 botulinum toxin substrate 3

2

20

High-throughput

0.789

High

1015420

RHOG
Rho-related GTP-binding protein RhoG

2

20

Small-scale

0.768

High

375494

RASK
GTPase KRas

2

20

High-throughput

0.754

High

169088

ML12B
Myosin regulatory light chain 12B

1

20

High-throughput

0.691

High

692693

CALL3
Calmodulin-like protein 3

1

16

High-throughput

0.691

High

848133

MAGA1
Melanoma-associated antigen 1

3

4

High-throughput

0.667

High

1111494

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

2

1

High-throughput

0.628

High

463508

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

601277

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

862838

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

17

High-throughput

0.618

High

952802

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

977987

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1111447

RAB35
Ras-related protein Rab-35

1

17

High-throughput

0.618

High

1111450

ZYX
Zyxin

1

7

High-throughput

0.618

High

1111458

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1111489

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

418660

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

11

High-throughput

0.611

High

1111474

DTBP1
Dysbindin

2

2

High-throughput

0.611

High

975021

ARF6
ADP-ribosylation factor 6

2

9

High-throughput

0.584

High

1111445

CUL3
Cullin-3

2

9

High-throughput

0.584

High

371966

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.558

High

407622

S100B
Protein S100-B

1

5

High-throughput

0.536

High

717803

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.536

High

783575

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

19

High-throughput

0.536

High

866377

MSS4
Guanine nucleotide exchange factor MSS4

1

1

High-throughput

0.536

High

905562

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.536

High

952554

MYL6
Myosin light polypeptide 6

1

20

High-throughput

0.536

High

1111456

DRC8
Dynein regulatory complex protein 8

1

20

High-throughput

0.536

High

1111462

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

2

High-throughput

0.536

High

1111469

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

16

High-throughput

0.536

High

1111471

TRI52
E3 ubiquitin-protein ligase TRIM52

1

10

High-throughput

0.536

High

1111473

ARRD3
Arrestin domain-containing protein 3

1

3

High-throughput

0.536

High

1111477

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

7

High-throughput

0.536

High

1111479

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

17

High-throughput

0.536

High

1111484

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

2

High-throughput

0.536

High

1111491

LATS2
Serine/threonine-protein kinase LATS2

1

9

High-throughput

0.536

High

1111498

HSPB8
Heat shock protein beta-8

1

4

High-throughput

0.536

High

830697

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

1045263

TF65
Transcription factor p65

1

7

High-throughput

0.515

High

407085

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

1111451

ASIC2
Acid-sensing ion channel 2

1

0

High-throughput

0.513

High

1111465

MIER2
Mesoderm induction early response protein 2

1

0

High-throughput

0.513

High

1111486

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

1111485

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.493

High

74483

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

4

High-throughput

0.489

High

848618

MAGA9
Melanoma-associated antigen 9

1

4

High-throughput

0.489

High

1111466

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

11

High-throughput

0.489

High

1111478

TCPQM
T-complex protein 1 subunit theta-like 2

1

2

High-throughput

0.489

High

1111481

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.489

High

1111487

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.489

High

278855

PEX14
Peroxisomal membrane protein PEX14

1

1

Small-scale

0.484

High

136889

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

3

High-throughput

0.479

High

293659

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

385721

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

4

High-throughput

0.479

High

400795

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.479

High

487282

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.479

High

507938

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

596980

TSHR
Thyrotropin receptor

1

3

High-throughput

0.479

High

629844

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

791370

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

934575

TERA
Transitional endoplasmic reticulum ATPase

1

8

Small-scale

0.479

High

1041048

CAV1
Caveolin-1

1

6

High-throughput

0.479

High

1091391

ANK3
Ankyrin-3

1

5

High-throughput

0.479

High

1107690

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1111446

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

1111448

IKBB
NF-kappa-B inhibitor beta

1

15

High-throughput

0.479

High

1111452

DPYL2
Dihydropyrimidinase-related protein 2

1

1

High-throughput

0.479

High

1111453

OCLN
Occludin

1

3

High-throughput

0.479

High

1111454

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1111457

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1111468

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1111470

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.479

High

1111472

CLUA1
Clusterin-associated protein 1

1

3

High-throughput

0.479

High

1111476

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1111480

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

10

High-throughput

0.479

High

1111482

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

7

High-throughput

0.479

High

1111490

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1111492

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1111496

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1111497

RABX5
Rab5 GDP/GTP exchange factor

1

2

High-throughput

0.479

High

1111500

UBQL1
Ubiquilin-1

1

1

High-throughput

0.479

High

595424

H15
Histone H1.5

1

2

High-throughput

0.470

High

1111493

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1093101

STK4
Serine/threonine-protein kinase 4

1

13

High-throughput

0.445

High

1111455

KLH22
Kelch-like protein 22

1

2

High-throughput

0.445

High

1111461

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

1111488

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

High-throughput

0.445

High

377568

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.437

High

588639

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

695397

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

768131

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1099861

TIF1B
Transcription intermediary factor 1-beta

1

14

High-throughput

0.437

High

1111459

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

1111460

ZCH18
Zinc finger CCCH domain-containing protein 18

1

7

High-throughput

0.437

High

1111463

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1111499

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.437

High

1111449

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

1111467

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.426

High

1111495

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

62507

S35F4
Solute carrier family 35 member F4

1

2

High-throughput

0.407

High

104143

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

653300

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

1111501

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

2

High-throughput

0.407

High

1111475

CH076
Uncharacterized protein C8orf76

1

0

High-throughput

0.279

Low

1111464

F186B
Protein FAM186B

1

0

High-throughput

0.249

Low

47873

A0AUL9
ATG2A protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025