HitPredict

Interactor 1: BMPR2 (Q13873)
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Gene: BMPR2

Interactor 2: GDF6 (Q6KF10)
Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
Gene: GDF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9525338
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0005615 - extracellular space GO:0030509 - BMP signaling pathway GO:0060391 - positive regulation of SMAD protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 455
+	Hs
		520153 BMPR2_HUMAN (1-1038): 0: 868: 100.00		BMP4_HUMAN (78-455): 1.22e-99: 306: 27.07
+	Hs
		574204 BMPR2_HUMAN (1-1038): 0: 868: 100.00		BMP7_HUMAN (80-454): 6.35e-97: 300: 24.08
+	Hs
		792921 BMPR2_HUMAN (1-1038): 0: 868: 100.00		GDF5_HUMAN (21-455): 5.17e-96: 299: 41.79
+	Hs
		602932 BMPR2_HUMAN (1-1038): 0: 868: 100.00		BMP6_HUMAN (50-454): 1.32e-94: 296: 23.08
+	Hs
		313008 BMPR2_HUMAN (1-1038): 0: 868: 100.00		BMP10_HUMAN (83-455): 4.8e-92: 286: 29.05
+	Hs
		520078 BMPR2_HUMAN (1-1038): 0: 868: 100.00		BMP2_HUMAN (78-455): 2.2e-90: 281: 26.01
+	Hs
		233940 BMPR2_HUMAN (1-1038): 0: 868: 100.00		GDF9_HUMAN (27-455): 1.89e-86: 273: 17.33
+	Hs
		1046389 BMPR2_HUMAN (1-1038): 0: 868: 100.00		GDF2_HUMAN (83-455): 3.03e-85: 269: 26.60
+	Hs
		439887 BMPR2_HUMAN (1-1038): 0: 868: 100.00		INHBA_HUMAN (14-454): 4.51e-80: 256: 22.80
+	Hs
		451821 BMPR2_HUMAN (1-1038): 0: 868: 100.00		INHBB_HUMAN (58-454): 2.29e-60: 204: 17.39
+	Hs
		738359 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		GDF6_HUMAN (1-455): 1.79e-156: 452: 100.00
+	Hs
		337369 ABL1_HUMAN (166-1016): 1.93e-137: 444: 15.47		BMP8B_HUMAN (91-454): 1.26e-88: 277: 26.77
+	Hs
		520110 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		BMP4_HUMAN (78-455): 1.22e-99: 306: 27.07
+	Hs
		574186 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		BMP7_HUMAN (80-454): 6.35e-97: 300: 24.08
+	Dm
		429970 Q24229_DROME (35-504): 6.45e-135: 418: 35.08		DECA_DROME (24-455): 2.1e-92: 293: 24.55
+	Hs
		738309 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		GDF5_HUMAN (21-455): 5.17e-96: 299: 41.79
+	Hs
		602926 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		BMP6_HUMAN (50-454): 1.32e-94: 296: 23.08
+	Hs
		520071 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		BMP2_HUMAN (78-455): 2.2e-90: 281: 26.01
+	Hs
		351286 BMR1A_HUMAN (51-510): 1.95e-132: 412: 28.75		TGFB1_HUMAN (41-454): 4.82e-78: 249: 19.72
+	Hs
		59851 AVR2B_HUMAN (11-513): 2.43e-125: 393: 34.37		A4D1W7_HUMAN (14-454): 4.51e-80: 256: 22.80