HitPredict

Interactor 1: PTK6 (Q13882)
Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)
Gene: PTK6

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 451 Hs			1 378
+	Hs
		412211 FYN_HUMAN (10-450): 0: 521: 42.35		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		523006 SRC_HUMAN (3-450): 0: 521: 43.30		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		433368 YES_HUMAN (10-450): 0: 519: 42.86		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		411738 LCK_HUMAN (3-449): 0: 517: 39.07		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		442838 HCK_HUMAN (4-449): 8.95e-179: 511: 39.82		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		454835 FGR_HUMAN (10-450): 3.32e-177: 508: 42.41		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		433785 LYN_HUMAN (3-449): 5.02e-177: 506: 38.19		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		789071 ABL2_HUMAN (2-449): 1.97e-164: 495: 35.02		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		846474 BLK_HUMAN (7-449): 2e-169: 487: 39.51		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		782791 CSK_HUMAN (4-448): 3.18e-160: 461: 35.82		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082984 SRMS_HUMAN (1-446): 1.22e-158: 459: 44.99		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082800 Q573B4_HUMAN (10-449): 4.25e-154: 448: 34.98		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		996564 ITK_HUMAN (7-447): 1.9e-152: 448: 32.82		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		788966 MATK_HUMAN (26-442): 7.22e-80: 258: 38.73		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00