HitPredict

Interactor 1: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31541095, 34315543
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PX, PH~RA, PDZ~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 803 Hs			1 541
+	Hs
		1049748 ARHG7_HUMAN (1-803): 0: 654: 100.00		SHAN1_HUMAN (43-169): 7.26e-32: 133: 30.71
+	Hs
		1049744 ARHG7_HUMAN (1-803): 0: 654: 100.00		SHAN2_HUMAN (43-147): 7.14e-29: 124: 38.10
+	Hs
		1049707 ARHG7_HUMAN (1-803): 0: 654: 100.00		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		1049728 ARHG7_HUMAN (1-803): 0: 654: 100.00		SHAN3_HUMAN (44-148): 1.57e-21: 101: 37.14
+	Mm
		1116136 ARHG7_MOUSE (1-797): 0: 570: 91.09		SHAN3_MOUSE (44-148): 2.57e-21: 100: 36.19
+	Hs
		1066045 ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48		NEB2_HUMAN (40-314): 3.95e-34: 139: 17.98
+	Hs
		1066026 ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Rn
		223055 ARHG7_RAT (180-802): 6.24e-133: 411: 83.97		SHAN1_RAT (43-183): 5e-32: 133: 30.28
+	Rn
		223054 ARHG7_RAT (180-802): 6.24e-133: 411: 83.97		SHAN2_RAT (43-147): 1.03e-28: 123: 38.10
+	Rn
		223053 ARHG7_RAT (180-802): 6.24e-133: 411: 83.97		SHAN3_RAT (44-149): 1.57e-21: 101: 35.85
+	Hs
		548744 VAV_HUMAN (1-778): 3.84e-111: 360: 16.96		NEB2_HUMAN (40-314): 3.95e-34: 139: 17.98
+	Hs
		548755 VAV_HUMAN (1-778): 3.84e-111: 360: 16.96		LIN7C_HUMAN (35-136): 1.5e-27: 111: 34.95
+	Hs
		1287792 Q96D37_HUMAN (55-778): 3.88e-93: 310: 15.20		NEB2_HUMAN (40-314): 3.95e-34: 139: 17.98
+	Mm
		1115909 SPT13_MOUSE (83-659): 2.83e-107: 344: 19.50		SHAN3_MOUSE (44-148): 2.57e-21: 100: 36.19
+	Mm
		57860 KALRN_MOUSE (34-664): 3.16e-70: 255: 14.55		Q7TN74_MOUSE (40-375): 2.98e-41: 161: 14.43
+	Mm
		57847 KALRN_MOUSE (34-664): 3.16e-70: 255: 14.55		SHAN3_MOUSE (44-148): 2.57e-21: 100: 36.19
+	Hs
		1075407 ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		1078902 ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68		SHAN3_HUMAN (44-148): 1.57e-21: 101: 37.14