HitPredict

Interactor 1: FHL2 (Q14192)
Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)
Gene: FHL2

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	19139564
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046872 - metal ion binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 279 Hs			1 467
+	Hs
		950180 FHL2_HUMAN (1-279): 4.64e-77: 237: 100.00		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		200171 TGFI1_HUMAN (3-218): 4.81e-69: 222: 26.39		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Mm
		1143672 TGFI1_MOUSE (3-218): 1.98e-68: 220: 26.39		SMAD3_MOUSE (1-467): 0: 617: 83.94
+	Hs
		1044596 FHL3_HUMAN (66-279): 2.11e-40: 143: 27.32		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		950173 FHL3_HUMAN (66-279): 2.11e-40: 143: 27.32		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1044540 FHL1_HUMAN (183-279): 8.68e-11: 63.4: 30.28		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		950247 PDLI5_HUMAN (157-274): 2.08e-30: 121: 24.58		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		950213 ZN329_HUMAN (3-126): 6.24e-26: 108: 13.61		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1078754 ZN251_HUMAN (3-176): 9.18e-33: 128: 12.84		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Hs
		950172 FHL1_HUMAN (183-279): 8.68e-11: 63.4: 30.28		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1035432 FHL2_HUMAN (1-279): 4.64e-77: 237: 100.00		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		200176 TGFI1_HUMAN (3-218): 4.81e-69: 222: 26.39		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		1035426 FHL3_HUMAN (66-279): 2.11e-40: 143: 27.32		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		167310 TGFI1_HUMAN (3-218): 4.81e-69: 222: 26.39		SMAD7_HUMAN (13-443): 2.55e-109: 331: 25.23
+	Hs
		1035425 FHL1_HUMAN (183-279): 8.68e-11: 63.4: 30.28		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58