HitPredict

Interactor 1: IF4A2 (Q14240)
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Gene: EIF4A2

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	33711283
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~DEAD
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 407 Hs			1 2610
+	Hs
		892930 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		1271692 DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		571631 DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		757798 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Sc
		485684 IF4A_YEAST (24-407): 7e-167: 474: 65.89		UFD4_YEAST (2031-2610): 2.7e-129: 448: 28.16
+	Hs
		304099 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		125295 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		304051 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		571603 DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125617 DDX17_HUMAN (25-407): 4.76e-131: 395: 31.20		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125142 DDX5_HUMAN (10-407): 3.86e-132: 394: 30.30		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		124993 DDX3X_HUMAN (2-406): 3.77e-128: 385: 29.51		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125203 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		757756 IF4A3_HUMAN (3-407): 2.28e-130: 382: 67.65		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Sc
		761942 DHH1_YEAST (33-403): 1.13e-98: 305: 43.67		RSP5_YEAST (2265-2608): 2.06e-105: 360: 20.86
+	Hs
		892780 IF4A1_HUMAN (3-407): 2.35e-159: 456: 89.88		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95