Protein: KPCE
Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)

Gene: KPCE, PRKCE
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q02156

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0002281 - macrophage activation involved in immune response
GO:0003785 - actin monomer binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

990115

1433Z
14-3-3 protein zeta/delta

5

20

Small-scale

0.919

High

468278

HS90B
Heat shock protein HSP 90-beta

4

20

Small-scale

0.875

High

461373

HS90A
Heat shock protein HSP 90-alpha

4

20

Small-scale

0.867

High

363151

EGFR
Epidermal growth factor receptor

3

16

High-throughput

0.843

High

1034998

CDC37
Hsp90 co-chaperone Cdc37

3

7

High-throughput

0.839

High

603238

KPCA
Protein kinase C alpha type

3

16

Small-scale

0.817

High

730522

1433S
14-3-3 protein sigma

3

20

High-throughput

0.817

High

971420

1433E
14-3-3 protein epsilon

3

2

High-throughput

0.817

High

1034978

KPCE
Protein kinase C epsilon type

3

15

Small-scale

0.805

High

578457

BRAF
Serine/threonine-protein kinase B-raf

2

8

Small-scale

0.776

High

291019

ADAP1
Arf-GAP with dual PH domain-containing protein 1

1

11

Small-scale

0.757

High

690919

1433T
14-3-3 protein theta

2

20

High-throughput

0.737

High

727768

DNJA1
DnaJ homolog subfamily A member 1

2

6

High-throughput

0.737

High

729757

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.737

High

966207

1433G
14-3-3 protein gamma

2

20

High-throughput

0.737

High

986995

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

8

High-throughput

0.737

High

1034980

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

2

6

High-throughput

0.737

High

1034990

RCN2
Reticulocalbin-2

2

4

High-throughput

0.737

High

1034997

NEDD8
Ubiquitin-like protein NEDD8

2

5

High-throughput

0.737

High

1035028

KS6B2
Ribosomal protein S6 kinase beta-2

2

17

Small-scale

0.737

High

167872

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.724

High

348110

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.698

High

177848

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

High-throughput

0.691

High

666235

KPCL
Protein kinase C eta type

1

19

High-throughput

0.691

High

1034991

FAK2
Protein-tyrosine kinase 2-beta

1

19

High-throughput

0.691

High

1035006

VRK3
Serine/threonine-protein kinase VRK3

1

14

High-throughput

0.691

High

1035008

ST32A
Serine/threonine-protein kinase 32A

1

17

High-throughput

0.691

High

1035021

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

19

High-throughput

0.691

High

1034993

KPCD1
Serine/threonine-protein kinase D1

1

17

Small-scale

0.666

High

400679

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

Small-scale

0.665

High

703539

MK01
Mitogen-activated protein kinase 1

1

8

Small-scale

0.665

High

1034987

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

17

Small-scale

0.647

High

1034996

ELAV1
ELAV-like protein 1

1

3

Small-scale

0.647

High

1035003

MARK2
Serine/threonine-protein kinase MARK2

1

7

Small-scale

0.647

High

1035005

GRP3
Ras guanyl-releasing protein 3

1

8

Small-scale

0.647

High

1035007

AFAP1
Actin filament-associated protein 1

1

5

Small-scale

0.647

High

1035026

OGFR
Opioid growth factor receptor

2

5

High-throughput

0.628

High

193550

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

20

Small-scale

0.618

High

241437

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.618

High

619029

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

Small-scale

0.618

High

838063

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

7

Small-scale

0.618

High

996431

ACTS
Actin, alpha skeletal muscle

1

6

Small-scale

0.618

High

1034985

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

Small-scale

0.618

High

1034994

KS6A2
Ribosomal protein S6 kinase alpha-2

1

19

Small-scale

0.618

High

1035027

IBTK
Inhibitor of Bruton tyrosine kinase

1

5

Small-scale

0.618

High

563641

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

Small-scale

0.586

High

832692

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.586

High

1035011

PP14A
Protein phosphatase 1 regulatory subunit 14A

1

3

Small-scale

0.586

High

663753

IL32
Interleukin-32

2

3

Small-scale

0.584

High

640856

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

Small-scale

0.578

High

992693

RACK1
Small ribosomal subunit protein RACK1

1

11

Small-scale

0.578

High

714609

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.575

High

1035002

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

240078

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

10

High-throughput

0.571

High

415508

HSPB1
Heat shock protein beta-1

2

12

High-throughput

0.571

High

424857

ADT2
ADP/ATP translocase 2

2

11

High-throughput

0.571

High

457375

TBB5
Tubulin beta chain

2

12

High-throughput

0.571

High

536997

HSP7C
Heat shock cognate 71 kDa protein

2

8

High-throughput

0.571

High

542762

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

1

High-throughput

0.571

High

549567

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

10

High-throughput

0.571

High

552203

ADT3
ADP/ATP translocase 3

2

11

High-throughput

0.571

High

697502

PYR1
Multifunctional protein CAD

2

1

High-throughput

0.571

High

760892

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

2

High-throughput

0.571

High

894532

GDIB
Rab GDP dissociation inhibitor beta

2

1

High-throughput

0.571

High

895433

SPB8
Serpin B8

2

4

High-throughput

0.571

High

895480

SPB9
Serpin B9

2

3

High-throughput

0.571

High

996665

TBA1B
Tubulin alpha-1B chain

2

9

High-throughput

0.571

High

997290

TBB4B
Tubulin beta-4B chain

2

12

High-throughput

0.571

High

1024332

S25A3
Solute carrier family 25 member 3

2

15

High-throughput

0.571

High

1027329

DHSO
Sorbitol dehydrogenase

2

1

High-throughput

0.571

High

1034981

AKA12
A-kinase anchor protein 12

2

3

High-throughput

0.571

High

1034988

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

2

4

High-throughput

0.571

High

1034989

KEAP1
Kelch-like ECH-associated protein 1

2

2

High-throughput

0.571

High

1034999

FSCN1
Fascin

2

3

High-throughput

0.571

High

1035000

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

2

1

High-throughput

0.571

High

1035001

TBB8
Tubulin beta-8 chain

2

12

High-throughput

0.571

High

1035018

TBA1C
Tubulin alpha-1C chain

2

10

High-throughput

0.571

High

1035025

BCLF1
Bcl-2-associated transcription factor 1

2

2

High-throughput

0.571

High

1035030

TR150
Thyroid hormone receptor-associated protein 3

2

2

High-throughput

0.571

High

211485

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

2

0

High-throughput

0.547

High

705812

AMPL
Cytosol aminopeptidase

2

0

High-throughput

0.547

High

728939

PUR9
Bifunctional purine biosynthesis protein ATIC

2

0

High-throughput

0.547

High

1035019

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

2

0

High-throughput

0.547

High

1035029

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.547

High

1035032

SERC
Phosphoserine aminotransferase

2

0

High-throughput

0.547

High

587626

DESP
Desmoplakin

1

7

High-throughput

0.541

High

1035010

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.537

High

1035016

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.537

High

370067

CYTS
Cystatin-S

1

1

High-throughput

0.536

High

479923

CYTT
Cystatin-SA

1

1

High-throughput

0.536

High

944795

PCBP3
Poly(rC)-binding protein 3

1

3

High-throughput

0.536

High

295426

SPI2
Serpin I2

2

4

High-throughput

0.521

High

721505

ILEU
Leukocyte elastase inhibitor

2

3

High-throughput

0.521

High

1035004

TCAM2
TIR domain-containing adapter molecule 2

1

1

Small-scale

0.516

High

1035017

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

2

Small-scale

0.515

High

421950

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.515

High

791307

SYUA
Alpha-synuclein

1

4

High-throughput

0.515

High

956138

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.513

High

1035012

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

1035020

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.513

High

1035031

T10B
Mitochondrial import inner membrane translocase subunit Tim10 B

1

0

High-throughput

0.513

High

424072

ITB2
Integrin beta-2

1

12

Small-scale

0.501

High

529658

TAU
Microtubule-associated protein tau

1

10

Small-scale

0.501

High

583537

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

2

High-throughput

0.501

High

593741

PECA1
Platelet endothelial cell adhesion molecule

1

1

Small-scale

0.501

High

889263

NUMB
Protein numb homolog

1

11

Small-scale

0.501

High

1034979

H11
Histone H1.1

1

18

Small-scale

0.501

High

1034982

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

6

Small-scale

0.501

High

1034984

DCE2
Glutamate decarboxylase 2

1

3

Small-scale

0.501

High

1034992

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

6

Small-scale

0.501

High

1035015

DCE1
Glutamate decarboxylase 1

1

3

Small-scale

0.501

High

1035023

NANOG
Homeobox protein NANOG

1

5

Small-scale

0.501

High

1035014

PDLI5
PDZ and LIM domain protein 5

1

16

Small-scale

0.481

High

407431

K2C1
Keratin, type II cytoskeletal 1

1

1

Small-scale

0.479

High

436846

K1C18
Keratin, type I cytoskeletal 18

1

2

Small-scale

0.479

High

437149

K2C8
Keratin, type II cytoskeletal 8

1

1

Small-scale

0.479

High

551991

ADT1
ADP/ATP translocase 1

1

11

Small-scale

0.479

High

603938

CXA1
Gap junction alpha-1 protein

1

8

Small-scale

0.479

High

772751

MYH9
Myosin-9

1

3

Small-scale

0.479

High

773482

COPB2
Coatomer subunit beta'

1

4

Small-scale

0.479

High

839145

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

5

Small-scale

0.479

High

1034983

KCNC4
Voltage-gated potassium channel KCNC4

1

5

Small-scale

0.479

High

1034986

BAX
Apoptosis regulator BAX

1

1

Small-scale

0.479

High

1035009

BAD
Bcl2-associated agonist of cell death

1

3

Small-scale

0.479

High

1035033

NEMO
NF-kappa-B essential modulator

1

13

Small-scale

0.479

High

294690

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.458

High

914074

HXK2
Hexokinase-2

1

0

Small-scale

0.458

High

1034995

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.458

High

90922

C6GKH1
Interleukin 32

1

3

Small-scale

0.437

High

105779

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1035024

UD17
UDP-glucuronosyltransferase 1A7

1

0

Small-scale

0.426

High

1035013

BPIA2
BPI fold-containing family A member 2

1

0

High-throughput

0.279

Low

1035022

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

517217

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025