HitPredict

Interactor 1: FLOT2 (Q14254)
Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)
Gene: FLOT2

Interactor 2: CHM4B (Q9H444)
Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)
Gene: CHMP4B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 31586073
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005886 - plasma membrane GO:0031982 - vesicle GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 428 Hs			1 224
+	Dm
		247512 FLOT2_DROME (1-427): 6.93e-146: 424: 63.18		CHM4_DROME (1-222): 3.22e-45: 151: 56.28
+	Dm
		247534 FLOT2_DROME (1-427): 6.93e-146: 424: 63.18		CHMP5_DROME (4-218): 6.48e-40: 138: 23.21
+	Hs
		279708 FLOT1_HUMAN (5-417): 1.06e-121: 362: 47.49		CHM4B_HUMAN (1-224): 3.19e-52: 169: 100.00
+	Dm
		247494 FLOT1_DROME (6-416): 5.19e-121: 360: 47.96		CHMP5_DROME (4-218): 6.48e-40: 138: 23.21
+	At
		1118401 FLOT2_ARATH (94-364): 1.65e-64: 215: 21.51		VP601_ARATH (4-221): 1.99e-48: 160: 19.23
+	At
		1118399 FLOT2_ARATH (94-364): 1.65e-64: 215: 21.51		VPS2C_ARATH (14-221): 2.15e-31: 116: 18.96
+	Hs
		646298 STOM_HUMAN (4-231): 6.87e-36: 135: 16.59		CHM4B_HUMAN (1-224): 3.19e-52: 169: 100.00
+	Hs
		1286740 STML2_HUMAN (26-220): 1.09e-16: 83: 19.90		CHM4C_HUMAN (1-221): 1.06e-47: 158: 60.78