Interactor 1: BECN1 (Q14457)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1

Interactor 2: BECN1 (Q14457)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 18641390, 29866835, 27383850, 28205554, 22314358, 24879154, 27304906, 24141421, 20501938, 19270696, 19050071, 20562859, 24034250
Identification Methods biochemical, pull down, affinity chromatography technology, x-ray crystallography, fluorescent resonance energy transfer, two hybrid, tandem affinity purification, cosedimentation in solution, anti tag coimmunoprecipitation
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains APG6~APG6_N, APG6_N~APG6_N, BH3~BH3
Common GO terms GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000423 - mitophagy
GO:0001666 - response to hypoxia
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
and 72 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 450
Hs

1 450
+ Mm
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024