Protein: BTK
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)

Gene: BTK
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q06187

Gene Ontology (top 5):
GO:0001780 - neutrophil homeostasis
GO:0001805 - positive regulation of type III hypersensitivity
GO:0001812 - positive regulation of type I hypersensitivity
GO:0002250 - adaptive immune response
GO:0002344 - B cell affinity maturation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054099

BTK
Tyrosine-protein kinase BTK

8

20

Small-scale

0.964

High

1054128

BLNK
B-cell linker protein

6

20

Small-scale

0.937

High

1054121

ANR54
Ankyrin repeat domain-containing protein 54

5

15

High-throughput

0.925

High

1054153

IBTK
Inhibitor of Bruton tyrosine kinase

3

6

Small-scale

0.870

High

461392

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.861

High

1054162

M3K4
Mitogen-activated protein kinase kinase kinase 4

3

4

High-throughput

0.855

High

987569

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.817

High

1054114

CDC37
Hsp90 co-chaperone Cdc37

2

13

High-throughput

0.811

High

468292

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.802

High

473402

HCK
Tyrosine-protein kinase HCK

2

19

Small-scale

0.799

High

1054139

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

2

7

High-throughput

0.789

High

1054150

TLR9
Toll-like receptor 9

2

14

Small-scale

0.775

High

1054151

TLR8
Toll-like receptor 8

2

14

Small-scale

0.775

High

1054130

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.767

High

838355

STA5A
Signal transducer and activator of transcription 5A

1

16

Small-scale

0.761

High

599285

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

16

Small-scale

0.754

High

1005849

GTF2I
General transcription factor II-I

6

1

Small-scale

0.741

High

1054112

KPCD1
Serine/threonine-protein kinase D1

1

13

Small-scale

0.724

High

366486

UROK
Urokinase-type plasminogen activator

1

2

High-throughput

0.698

High

882462

ARRB1
Beta-arrestin-1

1

8

High-throughput

0.698

High

842642

WASP
Actin nucleation-promoting factor WAS

4

20

Small-scale

0.696

High

472046

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

1054106

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

362256

ABL1
Tyrosine-protein kinase ABL1

1

18

Small-scale

0.691

High

386463

SPTA1
Spectrin alpha chain, erythrocytic 1

1

18

Small-scale

0.691

High

555667

ACTN1
Alpha-actinin-1

1

6

Small-scale

0.691

High

637470

FLNA
Filamin-A

1

10

Small-scale

0.691

High

710700

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.691

High

1054101

TWF1
Twinfilin-1

1

2

Small-scale

0.691

High

1054115

DREB
Drebrin

1

7

Small-scale

0.691

High

1054143

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

11

Small-scale

0.691

High

651293

CBL
E3 ubiquitin-protein ligase CBL

4

20

Small-scale

0.671

High

905548

IRAK1
Interleukin-1 receptor-associated kinase 1

1

14

Small-scale

0.665

High

1048281

KPCT
Protein kinase C theta type

1

20

Small-scale

0.665

High

126308

TLR4
Toll-like receptor 4

1

18

Small-scale

0.656

High

1054160

TLR6
Toll-like receptor 6

1

16

Small-scale

0.656

High

170100

AURKA
Aurora kinase A

1

16

Small-scale

0.647

High

436663

KPCB
Protein kinase C beta type

1

20

Small-scale

0.647

High

440507

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.647

High

463474

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.647

High

641578

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

658595

KS6B1
Ribosomal protein S6 kinase beta-1

1

20

Small-scale

0.647

High

1054119

RHG17
Rho GTPase-activating protein 17

1

20

Small-scale

0.647

High

1054146

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

12

Small-scale

0.647

High

1054154

KS6B2
Ribosomal protein S6 kinase beta-2

1

20

Small-scale

0.647

High

239420

3BP5
SH3 domain-binding protein 5

2

0

Small-scale

0.629

High

373895

RASN
GTPase NRas

1

20

High-throughput

0.618

High

374543

RASH
GTPase HRas

1

20

High-throughput

0.618

High

375439

RASK
GTPase KRas

1

20

High-throughput

0.618

High

413685

P53
Cellular tumor antigen p53

1

6

High-throughput

0.618

High

578463

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.618

High

584523

VAV
Proto-oncogene vav

1

20

Small-scale

0.618

High

658698

JAK1
Tyrosine-protein kinase JAK1

1

19

Small-scale

0.618

High

730531

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

827756

STAT3
Signal transducer and activator of transcription 3

1

16

Small-scale

0.618

High

849147

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

1054111

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.618

High

1054138

ARI3A
AT-rich interactive domain-containing protein 3A

2

1

Small-scale

0.594

High

946653

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

0

Small-scale

0.585

High

1054108

BECN1
Beclin-1

2

2

High-throughput

0.576

High

636070

CD11B
Cyclin-dependent kinase 11B

1

13

High-throughput

0.575

High

1054116

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

1054117

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.575

High

1054156

FEM1B
Protein fem-1 homolog B

1

8

High-throughput

0.575

High

1054124

TTC9C
Tetratricopeptide repeat protein 9C

2

15

High-throughput

0.574

High

893835

MEOX2
Homeobox protein MOX-2

1

8

High-throughput

0.573

High

1054100

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

19

Small-scale

0.563

High

893483

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

1

Small-scale

0.561

High

1028163

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.561

High

1054158

COR1C
Coronin-1C

1

5

Small-scale

0.553

High

519975

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

1054105

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.536

High

141439

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

Small-scale

0.536

High

253945

LPXN
Leupaxin

1

20

High-throughput

0.536

High

408829

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

Small-scale

0.536

High

443763

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

4

Small-scale

0.536

High

566364

K2C5
Keratin, type II cytoskeletal 5

1

2

Small-scale

0.536

High

655167

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

Small-scale

0.536

High

680326

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

4

Small-scale

0.536

High

996438

ACTS
Actin, alpha skeletal muscle

1

5

Small-scale

0.536

High

996917

TBA4A
Tubulin alpha-4A chain

1

8

Small-scale

0.536

High

997295

TBB4B
Tubulin beta-4B chain

1

6

Small-scale

0.536

High

1051736

EF1A2
Elongation factor 1-alpha 2

1

2

Small-scale

0.536

High

1054123

HORN
Hornerin

1

1

Small-scale

0.536

High

1054161

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

5

Small-scale

0.536

High

1011065

RT22
Small ribosomal subunit protein mS22

2

1

High-throughput

0.526

High

636211

MAL
Myelin and lymphocyte protein

1

4

Small-scale

0.515

High

1054137

MYD88
Myeloid differentiation primary response protein MyD88

1

15

Small-scale

0.515

High

1054144

MED28
Mediator of RNA polymerase II transcription subunit 28

1

8

Small-scale

0.515

High

76305

B4DMH3
Coronin

1

4

Small-scale

0.514

High

658129

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.513

High

421975

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

869476

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

12

Small-scale

0.501

High

1054102

COASY
Bifunctional coenzyme A synthase

1

2

Small-scale

0.501

High

1054141

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

6

Small-scale

0.501

High

829365

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

Small-scale

0.489

High

219619

B2L11
Bcl-2-like protein 11

1

0

Small-scale

0.480

High

222963

PRC1
Protein regulator of cytokinesis 1

1

10

High-throughput

0.479

High

675004

TNR6
Tumor necrosis factor receptor superfamily member 6

1

13

Small-scale

0.479

High

718688

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

3

Small-scale

0.479

High

832696

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.479

High

879001

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

11

High-throughput

0.479

High

940436

TCL1A
T-cell leukemia/lymphoma protein 1A

1

1

High-throughput

0.479

High

983460

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

Small-scale

0.479

High

1032914

EWS
RNA-binding protein EWS

1

3

Small-scale

0.479

High

1041021

CAV1
Caveolin-1

1

10

Small-scale

0.479

High

1054103

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

1054133

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1054148

GPVI
Platelet glycoprotein VI

1

16

Small-scale

0.479

High

1054149

PDE7B
3',5'-cyclic-AMP phosphodiesterase 7B

1

6

High-throughput

0.479

High

1054126

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

49105

BLT3B
Bridge-like lipid transfer protein family member 3B

1

4

High-throughput

0.445

High

240083

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

1

12

High-throughput

0.445

High

254983

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

379506

IGHM
Immunoglobulin heavy constant mu

1

6

Small-scale

0.445

High

409359

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.445

High

568630

GYS1
Glycogen [starch] synthase, muscle

1

1

High-throughput

0.445

High

583972

CD19
B-lymphocyte antigen CD19

1

2

Small-scale

0.445

High

604644

UBF1
Nucleolar transcription factor 1

1

6

High-throughput

0.445

High

1040720

ENL
Protein ENL

1

14

High-throughput

0.445

High

1054104

TCOF
Treacle protein

1

15

High-throughput

0.445

High

1054107

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.445

High

1054109

RFTN1
Raftlin

1

1

Small-scale

0.445

High

1054110

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

7

High-throughput

0.445

High

1054113

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.445

High

1054118

RN187
E3 ubiquitin-protein ligase RNF187

1

8

High-throughput

0.445

High

1054122

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.445

High

1054125

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

High-throughput

0.445

High

1054127

PNISR
Arginine/serine-rich protein PNISR

1

3

High-throughput

0.445

High

1054134

TRI44
Tripartite motif-containing protein 44

1

10

High-throughput

0.445

High

1054140

ACTBM
Putative beta-actin-like protein 3

1

6

Small-scale

0.445

High

1054142

OSBL6
Oxysterol-binding protein-related protein 6

1

2

High-throughput

0.445

High

1054145

PININ
Pinin

1

5

High-throughput

0.445

High

1054147

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

1

High-throughput

0.445

High

1054152

CXXC1
CXXC-type zinc finger protein 1

1

8

High-throughput

0.445

High

1054157

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

6

High-throughput

0.445

High

1054159

SET1B
Histone-lysine N-methyltransferase SETD1B

1

12

High-throughput

0.445

High

863412

GLYG
Glycogenin-1

1

0

High-throughput

0.426

High

1054132

ARK2N
Protein ARK2N

1

0

High-throughput

0.426

High

1054135

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.426

High

1054136

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.426

High

126096

AP3B1
AP-3 complex subunit beta-1

1

7

High-throughput

0.407

High

158814

AP3D1
AP-3 complex subunit delta-1

1

11

High-throughput

0.407

High

1054120

BLT3A
Bridge-like lipid transfer protein family member 3A

1

4

High-throughput

0.407

High

1054131

AP3S1
AP-3 complex subunit sigma-1

1

7

High-throughput

0.407

High

1054155

AFF4
AF4/FMR2 family member 4

1

7

High-throughput

0.407

High

702570

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

Small-scale

0.279

Low

1054129

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025