Protein: KLH22
Kelch-like protein 22

Gene: KLH22, KLHL22
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q53GT1

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1041715

CUL3
Cullin-3

12

20

Small-scale

0.977

High

1121278

KLH13
Kelch-like protein 13

6

19

Small-scale

0.941

High

1121277

KLHL9
Kelch-like protein 9

4

19

Small-scale

0.892

High

1121285

KLH20
Kelch-like protein 20

2

19

High-throughput

0.811

High

1121224

KLH26
Kelch-like protein 26

3

19

High-throughput

0.765

High

1121234

KAISO
Transcriptional regulator Kaiso

1

1

High-throughput

0.691

High

1121246

SHKB1
SH3KBP1-binding protein 1

1

4

High-throughput

0.691

High

1121250

NACC2
Nucleus accumbens-associated protein 2

1

19

High-throughput

0.691

High

1121276

KLH14
Kelch-like protein 14

1

19

High-throughput

0.691

High

1121287

IPP
Actin-binding protein IPP

1

19

High-throughput

0.691

High

1121236

NUDC3
NudC domain-containing protein 3

3

20

High-throughput

0.667

High

1121253

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.656

High

861780

PLK1
Serine/threonine-protein kinase PLK1

2

2

Small-scale

0.646

High

335123

DHE3
Glutamate dehydrogenase 1, mitochondrial

2

1

High-throughput

0.628

High

878594

ALR
FAD-linked sulfhydryl oxidase ALR

2

1

High-throughput

0.628

High

1121245

RB15B
Putative RNA-binding protein 15B

2

2

High-throughput

0.628

High

1121270

LYRM4
LYR motif-containing protein 4

2

1

High-throughput

0.628

High

1121280

CIZ1
Cip1-interacting zinc finger protein

2

2

High-throughput

0.628

High

1121283

SCAF8
SR-related and CTD-associated factor 8

2

2

High-throughput

0.628

High

1121231

CSN6
COP9 signalosome complex subunit 6

2

11

High-throughput

0.621

High

1121249

CSN5
COP9 signalosome complex subunit 5

2

12

High-throughput

0.621

High

1121244

ZBT34
Zinc finger and BTB domain-containing protein 34

1

8

High-throughput

0.618

High

267162

GEMI
Geminin

2

0

High-throughput

0.602

High

1121240

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.602

High

1121254

ATG4C
Cysteine protease ATG4C

2

0

High-throughput

0.602

High

1121259

RBM14
RNA-binding protein 14

2

0

High-throughput

0.602

High

1121279

TRM6
tRNA

2

0

High-throughput

0.602

High

1121281

NOB1
RNA-binding protein NOB1

2

0

High-throughput

0.602

High

1121288

NFS1
Cysteine desulfurase

2

0

High-throughput

0.602

High

529212

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.601

High

1121260

GPA33
Cell surface A33 antigen

1

0

High-throughput

0.578

High

259450

NIPS2
Protein NipSnap homolog 2

2

1

High-throughput

0.574

High

828155

DHE4
Glutamate dehydrogenase 2, mitochondrial

2

1

High-throughput

0.574

High

1121237

MICU2
Calcium uptake protein 2, mitochondrial

2

1

High-throughput

0.574

High

1121257

SREC2
Scavenger receptor class F member 2

2

1

High-throughput

0.574

High

1121261

MICU1
Calcium uptake protein 1, mitochondrial

2

1

High-throughput

0.574

High

199902

SPIT2
Kunitz-type protease inhibitor 2

1

4

High-throughput

0.536

High

239147

CTND1
Catenin delta-1

1

1

High-throughput

0.536

High

299387

UBXN7
UBX domain-containing protein 7

1

6

High-throughput

0.536

High

304624

SCAF4
SR-related and CTD-associated factor 4

1

3

High-throughput

0.536

High

569090

DESM
Desmin

1

3

High-throughput

0.536

High

621791

PRTN3
Myeloblastin

1

2

High-throughput

0.536

High

822041

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.536

High

822281

KC1D
Casein kinase I isoform delta

1

2

High-throughput

0.536

High

830381

KC1E
Casein kinase I isoform epsilon

1

4

High-throughput

0.536

High

854963

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

4

High-throughput

0.536

High

882919

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.536

High

979309

UBXN1
UBX domain-containing protein 1

1

6

High-throughput

0.536

High

986134

REG3A
Regenerating islet-derived protein 3-alpha

1

3

High-throughput

0.536

High

1023283

TRI32
E3 ubiquitin-protein ligase TRIM32

1

3

High-throughput

0.536

High

1052073

MAP7
Ensconsin

1

4

High-throughput

0.536

High

1079517

NEDD8
NEDD8

1

3

High-throughput

0.536

High

1121232

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

1

4

High-throughput

0.536

High

1121248

MZB1
Marginal zone B- and B1-cell-specific protein

1

3

High-throughput

0.536

High

1121255

DCNL1
DCN1-like protein 1

1

11

High-throughput

0.536

High

1121262

PDD2L
Programmed cell death protein 2-like

1

1

High-throughput

0.536

High

1121264

PDIP3
Polymerase delta-interacting protein 3

1

1

High-throughput

0.536

High

1121265

REG4
Regenerating islet-derived protein 4

1

3

High-throughput

0.536

High

1121266

PDGFD
Platelet-derived growth factor D

1

3

High-throughput

0.536

High

1121282

FAF1
FAS-associated factor 1

1

7

High-throughput

0.536

High

1121284

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.536

High

722939

ADA1A
Alpha-1A adrenergic receptor

1

0

High-throughput

0.518

High

1025775

TADBP
TAR DNA-binding protein 43

1

7

High-throughput

0.515

High

353214

LV657
Immunoglobulin lambda variable 6-57

1

4

High-throughput

0.514

High

936047

HBA
Hemoglobin subunit alpha

1

0

High-throughput

0.513

High

1121239

PNKD
Probable hydrolase PNKD

1

0

High-throughput

0.513

High

1121242

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

1121267

SAV1
Protein salvador homolog 1

1

0

High-throughput

0.513

High

126388

MATN2
Matrilin-2

1

1

High-throughput

0.489

High

134302

CCL21
C-C motif chemokine 21

1

2

High-throughput

0.489

High

134540

FCN1
Ficolin-1

1

1

High-throughput

0.489

High

450654

PAEP
Glycodelin

1

1

High-throughput

0.489

High

596137

C4BPB
C4b-binding protein beta chain

1

1

High-throughput

0.489

High

610666

IBP4
Insulin-like growth factor-binding protein 4

1

4

High-throughput

0.489

High

677826

LCN1
Lipocalin-1

1

1

High-throughput

0.489

High

1020127

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

1

High-throughput

0.489

High

1077630

KISS1
Metastasis-suppressor KiSS-1

1

3

High-throughput

0.489

High

1121230

SYDE1
Rho GTPase-activating protein SYDE1

1

3

High-throughput

0.489

High

1121233

RM10
Large ribosomal subunit protein uL10m

1

1

High-throughput

0.489

High

1121235

CILP2
Cartilage intermediate layer protein 2

1

1

High-throughput

0.489

High

1121263

RPP25
Ribonuclease P protein subunit p25

1

1

High-throughput

0.489

High

431924

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

438235

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

749563

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

818116

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

896118

UBC12
NEDD8-conjugating enzyme Ubc12

1

15

High-throughput

0.479

High

1121229

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1121247

BICD2
Protein bicaudal D homolog 2

1

4

High-throughput

0.479

High

1121269

NANOG
Homeobox protein NANOG

1

1

Small-scale

0.479

High

1121272

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1121286

ARI1
E3 ubiquitin-protein ligase ARIH1

1

12

High-throughput

0.479

High

305180

UBE4B
Ubiquitin conjugation factor E4 B

1

0

Small-scale

0.458

High

1121275

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1121289

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.458

High

607998

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.457

High

384952

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

354070

IGHA1
Immunoglobulin heavy constant alpha 1

1

3

High-throughput

0.407

High

49142

TM223
Transmembrane protein 223

2

0

High-throughput

0.328

High

63367

MET15
12S rRNA N4-methylcytidine

2

0

High-throughput

0.328

High

1121225

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

2

0

High-throughput

0.328

High

1121227

ETFR1
Electron transfer flavoprotein regulatory factor 1

2

0

High-throughput

0.328

High

1121243

NOA1
Nitric oxide-associated protein 1

2

0

High-throughput

0.328

High

1121258

FMC1
Protein FMC1 homolog

2

0

High-throughput

0.328

High

1121271

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

2

0

High-throughput

0.328

High

1121290

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

2

0

High-throughput

0.328

High

127510

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.279

Low

237071

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

High-throughput

0.279

Low

361694

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

375692

PA21B
Phospholipase A2

1

0

High-throughput

0.279

Low

528105

BMP1
Bone morphogenetic protein 1

1

0

High-throughput

0.279

Low

574212

BMP7
Bone morphogenetic protein 7

1

0

High-throughput

0.279

Low

1121226

LYRM7
Complex III assembly factor LYRM7

1

0

High-throughput

0.279

Low

1121228

TM154
Transmembrane protein 154

1

0

High-throughput

0.279

Low

1121238

RBFA
Putative ribosome-binding factor A, mitochondrial

1

0

High-throughput

0.279

Low

1121241

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.279

Low

1121251

CTHR1
Collagen triple helix repeat-containing protein 1

1

0

High-throughput

0.279

Low

1121252

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.279

Low

1121256

F163A
Protein FAM163A

1

0

High-throughput

0.279

Low

1121268

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

1121273

GKN1
Gastrokine-1

1

0

High-throughput

0.279

Low

1121274

LYRM2
LYR motif-containing protein 2

1

0

High-throughput

0.279

Low

541259

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

484830

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024