HitPredict

Interactor 1: BECN1 (Q14457)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	29326710, 30258449, 32384667, 33172060, 20501938, 29929436
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000045 - autophagosome assembly GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010008 - endosome membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 450 Hs			1 522
+	Mm
		291954 BECN1_MOUSE (1-450): 0: 633: 98.00		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1020658 BECN1_HUMAN (1-450): 0: 645: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		584962 BECN1_HUMAN (1-450): 0: 645: 100.00		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		1054158 BECN1_HUMAN (1-450): 0: 645: 100.00		TRI50_HUMAN (60-403): 1.01e-39: 152: 14.12