Protein: GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1)

Gene: GFPT1
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q06210

Gene Ontology (top 5):
GO:0004360 - glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0005829 - cytosol
GO:0006002 - fructose 6-phosphate metabolic process
GO:0006047 - UDP-N-acetylglucosamine metabolic process
GO:0006048 - UDP-N-acetylglucosamine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317448

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

3

10

High-throughput

0.855

High

1054312

SIR6
NAD-dependent protein deacylase sirtuin-6

3

3

High-throughput

0.656

High

1054278

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

10

Small-scale

0.647

High

241477

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

537027

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.559

High

563668

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

930680

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

2

High-throughput

0.536

High

1054280

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

High-throughput

0.536

High

853658

MK08
Mitogen-activated protein kinase 8

1

0

High-throughput

0.518

High

830609

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

1054307

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1054335

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.513

High

156034

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.493

High

131977

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

141440

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

157269

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

225569

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

1

High-throughput

0.479

High

380009

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

400699

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

404000

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

507867

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

Small-scale

0.479

High

549572

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.479

High

766478

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

876836

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

887998

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

970382

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1054281

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

1054283

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

1054285

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1054289

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1054304

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

Small-scale

0.479

High

1054306

DCP2
m7GpppN-mRNA hydrolase

1

1

High-throughput

0.479

High

1054317

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

1054319

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.479

High

1054321

OPTN
Optineurin

1

1

High-throughput

0.479

High

1054322

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1054326

TRIM6
Tripartite motif-containing protein 6

1

1

Small-scale

0.479

High

1054331

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1054340

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

1054341

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

415522

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.458

High

529684

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

609990

VGFR1
Vascular endothelial growth factor receptor 1

1

0

High-throughput

0.458

High

764689

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

791323

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

891481

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

1023426

AT8B2
Phospholipid-transporting ATPase ID

1

0

High-throughput

0.458

High

1035555

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1045206

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1054284

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1054288

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1054290

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1054291

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1054292

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.458

High

1054294

TECT1
Tectonic-1

1

0

High-throughput

0.458

High

1054296

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1054298

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1054303

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1054318

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1054320

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1054323

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

1054325

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

1054329

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1054332

ANLN
Anillin

1

0

High-throughput

0.458

High

1054339

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1054342

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

1054343

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

0

High-throughput

0.458

High

934512

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

1054295

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1054297

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

1054333

S17A5
Sialin

1

1

High-throughput

0.445

High

1054336

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.445

High

1054279

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

259841

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

293602

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

332102

MRP6
ATP-binding cassette sub-family C member 6

1

2

Small-scale

0.437

High

411789

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

588530

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

695279

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

768020

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

787153

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.437

High

964877

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

1054282

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

1054286

CUL4A
Cullin-4A

1

4

High-throughput

0.437

High

1054287

DX39B
Spliceosome RNA helicase DDX39B

1

2

Small-scale

0.437

High

1054300

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1054330

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1054334

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.437

High

756160

MCM7
DNA replication licensing factor MCM7

1

4

Small-scale

0.407

High

844758

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

844923

EAA2
Excitatory amino acid transporter 2

1

1

High-throughput

0.407

High

1054301

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.407

High

1054327

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

371840

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.298

High

249123

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

1054293

ZN423
Zinc finger protein 423

1

0

High-throughput

0.279

Low

1054314

F169B
Protein FAM169BP

1

0

High-throughput

0.279

Low

1054324

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

194152

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

276117

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

353275

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

376811

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.249

Low

377549

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

590888

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

642820

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

837571

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

897760

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.249

Low

1024520

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

1054299

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1054302

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1054305

HOOK3
Protein Hook homolog 3

1

0

High-throughput

0.249

Low

1054308

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1054309

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1054310

NIN
Ninein

1

0

High-throughput

0.249

Low

1054311

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

1054313

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1054315

POC5
Centrosomal protein POC5

1

0

High-throughput

0.249

Low

1054316

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1054328

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1054338

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

1054344

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1054345

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.249

Low

429767

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

1054337

S39A9
Zinc transporter ZIP9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025