HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: SMC5 (Q8IY18)
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
Gene: SMC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29656893, 36373674
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035861 - site of double-strand break
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 1101
+	Hs
		1056947 MDC1_HUMAN (1-2089): 0: 665: 100.00		SMC6_HUMAN (9-1069): 7.85e-63: 235: 15.55
+	Hs
		1019016 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221882 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		801238 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		801470 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		1019097 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		SMC6_HUMAN (9-1069): 7.85e-63: 235: 15.55
+	Hs
		1154049 NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1221841 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1173281 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		1221873 PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		801325 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		SMC6_HUMAN (9-1069): 7.85e-63: 235: 15.55
+	Hs
		1221669 MINT_HUMAN (159-1473): 1.72e-10: 68.9: 10.33		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		311568 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		SMC2_HUMAN (51-1055): 9.8e-55: 210: 11.41
+	Hs
		1154087 NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		1101620 MGAL_HUMAN (1423-1937): 8.53e-12: 73.1: 13.83		SMC4_HUMAN (2-1073): 2.02e-73: 268: 12.37
+	Hs
		725139 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60