HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: TNR6A (Q8NDV7)
Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)
Gene: TNRC6A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28813667
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2089 Hs			1 1962
+	Hs
		1019028 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		TNR6A_HUMAN (1-1962): 0: 896: 100.00
+	Hs
		1056910 MDC1_HUMAN (1-2089): 0: 665: 100.00		CBP_HUMAN (735-1745): 8.61e-21: 102: 9.54
+	Hs
		1056898 MDC1_HUMAN (1-2089): 0: 665: 100.00		ARI1B_HUMAN (551-1540): 1.58e-09: 65.5: 8.99
+	Hs
		998710 MDC1_HUMAN (1-2089): 0: 665: 100.00		EP300_HUMAN (789-1765): 6.73e-09: 63.6: 9.05
+	Hs
		1302939 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		MINT_HUMAN (30-1804): 8.51e-28: 125: 8.46
+	Hs
		1019050 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CBP_HUMAN (735-1745): 8.61e-21: 102: 9.54
+	Hs
		1270850 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		CBP_HUMAN (735-1745): 8.61e-21: 102: 9.54
+	Hs
		801326 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		MINT_HUMAN (30-1804): 8.51e-28: 125: 8.46
+	Hs
		1019030 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		ARI1B_HUMAN (551-1540): 1.58e-09: 65.5: 8.99
+	Hs
		998621 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		EP300_HUMAN (789-1765): 6.73e-09: 63.6: 9.05
+	Mm
		1157867 PAXI1_MOUSE (1840-2081): 5.99e-54: 209: 29.80		KMT2C_MOUSE (978-1884): 1.32e-29: 132: 11.29
+	Hs
		999262 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		EP300_HUMAN (789-1765): 6.73e-09: 63.6: 9.05
+	Hs
		801437 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		CHD7_HUMAN (1210-1768): 5.37e-15: 83.6: 12.63
+	Hs
		801438 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		RRBP1_HUMAN (329-778): 2.37e-09: 65.1: 13.30
+	Hs
		1173188 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2C_HUMAN (1071-1765): 1.31e-13: 79.4: 10.54
+	Hs
		998829 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		EP300_HUMAN (789-1765): 6.73e-09: 63.6: 9.05
+	Hs
		311825 TACC2_HUMAN (151-1928): 1.23e-24: 115: 9.64		CBP_HUMAN (735-1745): 8.61e-21: 102: 9.54
+	Hs
		311805 TACC2_HUMAN (151-1928): 1.23e-24: 115: 9.64		EP300_HUMAN (789-1765): 6.73e-09: 63.6: 9.05
+	Hs
		998981 ZN469_HUMAN (108-1444): 1.39e-21: 105: 8.20		EP300_HUMAN (789-1765): 6.73e-09: 63.6: 9.05
+	Hs
		999222 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		EP300_HUMAN (789-1765): 6.73e-09: 63.6: 9.05