HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	19826003
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016604 - nuclear body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2089 Hs			1 2442
+	Hs
		998710 MDC1_HUMAN (1-2089): 0: 665: 100.00		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		1019050 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		1270850 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		311825 TACC2_HUMAN (151-1928): 1.23e-24: 115: 9.64		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		998621 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		999262 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		998829 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		311805 TACC2_HUMAN (151-1928): 1.23e-24: 115: 9.64		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		998981 ZN469_HUMAN (108-1444): 1.39e-21: 105: 8.20		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		999222 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		1057027 MDC1_HUMAN (1-2089): 0: 665: 100.00		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Hs
		1056838 MDC1_HUMAN (1-2089): 0: 665: 100.00		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		631425 MDC1_HUMAN (1-2089): 0: 665: 100.00		BRD2_HUMAN (1065-1195): 9.64e-34: 143: 30.53
+	Hs
		1262850 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		PHIP_HUMAN (1045-1205): 3.22e-45: 183: 30.36
+	Hs
		1019179 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		TRI33_HUMAN (694-1207): 3.25e-37: 156: 14.83
+	Hs
		801155 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89
+	Hs
		801437 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		CHD7_HUMAN (70-467): 2.16e-11: 72.1: 9.68
+	Mm
		1157867 PAXI1_MOUSE (1840-2081): 5.99e-54: 209: 29.80		KMT2C_MOUSE (1733-2440): 7.05e-13: 77.1: 11.27
+	Hs
		1173188 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89
+	Hs
		1067006 NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13		BRD3_HUMAN (1073-1195): 1.36e-33: 143: 30.89