HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: RAD50 (Q92878)
DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)
Gene: RAD50

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	12607003, 30179224, 14519663, 29656893, 22833675, 12607005, 18583988
Identification Methods	affinity chromatography technology, proximity labelling technology, unspecified method, pull down, coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006974 - DNA damage response GO:0035861 - site of double-strand break
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2089 Hs			1 1312
+	Hs
		1056828 MDC1_HUMAN (1-2089): 0: 665: 100.00		SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17
+	Hs
		148818 MDC1_HUMAN (1-2089): 0: 665: 100.00		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		1019053 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		RAD50_HUMAN (1-1312): 1.28e-115: 394: 100.00
+	Hs
		1173200 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		RAD50_HUMAN (1-1312): 1.28e-115: 394: 100.00
+	Dm
		58922 A2VEF9_DROME (913-2046): 1.95e-56: 218: 11.68		RAD50_DROME (1-1303): 1.57e-72: 268: 26.79
+	Hs
		801145 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17
+	Hs
		502905 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		MYH3_HUMAN (785-1231): 2.95e-12: 74: 11.60
+	Hs
		148502 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		1113795 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		GRDN_HUMAN (530-1217): 5.01e-21: 102: 12.32
+	Hs
		1057296 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17
+	Hs
		1057338 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17
+	Hs
		551790 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		DESP_HUMAN (190-1069): 1.96e-10: 67.8: 18.71
+	Hs
		1057289 NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13		SMC1A_HUMAN (290-1274): 4.82e-19: 95.7: 11.17
+	Hs
		724782 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		MYH9_HUMAN (474-1226): 2.43e-26: 119: 10.19
+	Dm
		404245 TITIN_DROME (757-1667): 2e-11: 72: 12.37		MYSA_DROME (74-929): 3.37e-23: 109: 13.56
+	Hs
		148941 NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		149429 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		725139 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		MYH10_HUMAN (44-596): 1.31e-16: 88.3: 13.20
+	Hs
		149467 PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15
+	Hs
		149481 PCLO_HUMAN (76-1749): 3.04e-09: 64.9: 8.08		CTRO_HUMAN (732-1116): 8.66e-10: 65.7: 12.15