HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 665
+	Hs
		1285227 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		801212 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		DNMBP_HUMAN (104-607): 3.03e-16: 85.1: 15.82
+	Hs
		924760 PRG4_HUMAN (260-1225): 4.33e-17: 90.5: 9.80		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		557660 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924484 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		554292 MUC1_HUMAN (762-1525): 1.68e-11: 72: 18.23		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		557777 MINT_HUMAN (159-1473): 1.72e-10: 68.9: 10.33		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924808 MINT_HUMAN (159-1473): 1.72e-10: 68.9: 10.33		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91