HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	22990118
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 334
+	Hs
		805528 MDC1_HUMAN (1-2089): 0: 665: 100.00		BRCC3_HUMAN (56-203): 4.61e-43: 152: 21.23
+	Hs
		1019055 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		130868 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		1264776 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1272707 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		176965 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		EIF3H_HUMAN (52-320): 2.17e-66: 214: 18.57
+	Hs
		805525 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		BRCC3_HUMAN (56-203): 4.61e-43: 152: 21.23
+	Hs
		177045 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		EIF3H_HUMAN (52-320): 2.17e-66: 214: 18.57
+	Hs
		805539 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		BRCC3_HUMAN (56-203): 4.61e-43: 152: 21.23
+	Hs
		177112 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		EIF3H_HUMAN (52-320): 2.17e-66: 214: 18.57
+	Hs
		131125 PCLO_HUMAN (76-1749): 3.04e-09: 64.9: 8.08		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		124959 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48