HitPredict

Interactor 1: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Interactor 2: H2B1H (Q93079)
Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)
Gene: H2BC9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0046982 - protein heterodimerization activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1233 Hs			1 126
+	Hs
		707632 SMC1A_HUMAN (1-1233): 1.94e-128: 427: 100.00		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		1087272 SMC1B_HUMAN (1-1233): 1.24e-111: 380: 53.12		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		311555 SMC2_HUMAN (3-1214): 1.55e-77: 281: 17.57		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		1274480 SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00		H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00
+	Hs
		420896 SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00		H2B1J_HUMAN (1-126): 7.3e-55: 169: 97.62
+	Hs
		241662 SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		918774 SMC3_HUMAN (3-1229): 1.52e-70: 260: 16.00		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Sc
		355931 SMC3_YEAST (3-1215): 1.17e-78: 285: 18.20		H2B2_YEAST (3-125): 4.15e-41: 134: 71.55
+	Sc
		355537 SMC3_YEAST (3-1215): 1.17e-78: 285: 18.20		H2B1_YEAST (4-125): 8.17e-37: 123: 72.13
+	Sc
		355483 SMC2_YEAST (3-1213): 1.16e-73: 270: 16.83		H2B1_YEAST (4-125): 8.17e-37: 123: 72.13
+	Sc
		355421 SMC1_YEAST (1-1225): 1.18e-71: 264: 27.11		H2B1_YEAST (4-125): 8.17e-37: 123: 72.13
+	Hs
		724951 MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62		H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00
+	Hs
		241463 MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		724751 MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		724734 MYH9_HUMAN (49-760): 1.43e-25: 117: 11.62		H2B1D_HUMAN (1-126): 3.03e-54: 167: 98.41
+	Hs
		1274476 MYH2_HUMAN (495-1125): 5.14e-20: 99: 9.49		H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00