HitPredict

Interactor 1: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Interactor 2: C8AP2 (Q9UKL3)
CASP8-associated protein 2 (FLICE-associated huge protein)
Gene: CASP8AP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.63 0.60 0.616

The method score is based on:

Property Details
Experiments 10235259, 17245429
Identification Methods affinity chromatography technology, coimmunoprecipitation, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005123 - death receptor binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
and 2 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 479
Hs

1 1982
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024