HitPredict

Interactor 1: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Interactor 2: SHPRH (Q149N8)
E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)
Gene: SHPRH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Chromo~SNF2-rel_dom, Helicase_C~Helicase_C, Helicase_C~SNF2-rel_dom, SNF2-rel_dom~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0004386 - helicase activity GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0140658 - ATP-dependent chromatin remodeler activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1912 Hs			1 1683
+	Hs
		1018487 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SHPRH_HUMAN (1-1683): 0: 1247: 100.00
+	Hs
		1061766 CHD5_HUMAN (86-1909): 0: 1584: 71.18		SHPRH_HUMAN (1-1683): 0: 1247: 100.00
+	Hs
		1059751 CHD4_HUMAN (1-1912): 0: 1719: 100.00		CHD5_HUMAN (1253-1682): 1.55e-104: 373: 17.96
+	Hs
		229399 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMCA5_HUMAN (1267-1682): 2.48e-107: 370: 15.44
+	Hs
		1018483 CHD4_HUMAN (1-1912): 0: 1719: 100.00		CHD3_HUMAN (1279-1682): 6.88e-103: 368: 17.87
+	Hs
		846970 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMCA4_HUMAN (1246-1682): 3.38e-96: 346: 13.91
+	Hs
		1059614 CHD4_HUMAN (1-1912): 0: 1719: 100.00		CHD4_HUMAN (1275-1682): 1.8e-95: 345: 17.70
+	Hs
		846775 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMCA2_HUMAN (1161-1676): 4.99e-95: 342: 13.08
+	Hs
		658672 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMCA1_HUMAN (1315-1682): 8.95e-71: 261: 16.12
+	Hs
		1018602 CHD3_HUMAN (23-1905): 0: 1595: 66.89		CHD5_HUMAN (1253-1682): 1.55e-104: 373: 17.96
+	Hs
		229379 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SMCA5_HUMAN (1267-1682): 2.48e-107: 370: 15.44
+	Hs
		1018442 CHD3_HUMAN (23-1905): 0: 1595: 66.89		CHD3_HUMAN (1279-1682): 6.88e-103: 368: 17.87
+	Hs
		846950 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SMCA4_HUMAN (1246-1682): 3.38e-96: 346: 13.91
+	Hs
		846763 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SMCA2_HUMAN (1161-1676): 4.99e-95: 342: 13.08
+	Hs
		658660 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SMCA1_HUMAN (1315-1682): 8.95e-71: 261: 16.12
+	Hs
		1059895 CHD4_HUMAN (1-1912): 0: 1719: 100.00		HELLS_HUMAN (689-1006): 1.51e-25: 117: 15.67
+	Dm
		332724 CHDM_DROME (1-1904): 0: 1364: 50.85		CHDM_DROME (1255-1682): 1.2e-97: 352: 15.95