Protein: NOP6
Nucleolar protein 6

Gene: NOP6
Organism: Saccharomyces cerevisiae S288C
Interactions: 146
UniProt ID: Q07623

Gene Ontology (top 5):
GO:0001731 - formation of translation preinitiation complex
GO:0005730 - nucleolus
GO:0019843 - rRNA binding
GO:0030490 - maturation of SSU-rRNA
GO:0030515 - snoRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

844633

UTP10
U3 small nucleolar RNA-associated protein 10

5

0

High-throughput

0.684

High

677587

KRR1
KRR1 small subunit processome component

4

0

High-throughput

0.664

High

1050182

RRP5
rRNA biogenesis protein RRP5

4

0

High-throughput

0.664

High

700302

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

4

0

Small-scale

0.657

High

763637

UTP20
U3 small nucleolar RNA-associated protein 20

3

0

High-throughput

0.638

High

738269

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

3

0

High-throughput

0.638

High

782461

RPF2
Ribosome biogenesis protein RPF2

3

0

High-throughput

0.634

High

751498

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

0

High-throughput

0.628

High

1046057

DHR1
Probable ATP-dependent RNA helicase DHR1

3

0

High-throughput

0.628

High

1056485

UTP4
U3 small nucleolar RNA-associated protein 4

2

1

High-throughput

0.611

High

1059616

BMS1
Ribosome biogenesis protein BMS1

2

1

High-throughput

0.611

High

666557

DBP2
ATP-dependent RNA helicase DBP2

2

0

High-throughput

0.588

High

678472

PWP2
Periodic tryptophan protein 2

2

0

High-throughput

0.585

High

689691

RS7A
Small ribosomal subunit protein eS7A

2

0

High-throughput

0.585

High

1059611

RCL1
rRNA processing protein RCL1

2

0

High-throughput

0.585

High

1059621

NOP58
Nucleolar protein 58

2

0

High-throughput

0.585

High

513249

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.559

High

798327

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

1059619

YRA1
RNA annealing protein YRA1

2

1

High-throughput

0.558

High

924197

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

High-throughput

0.541

High

584281

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

2

High-throughput

0.536

High

746680

DRS1
ATP-dependent RNA helicase DRS1

1

2

High-throughput

0.536

High

781659

DBP7
ATP-dependent RNA helicase DBP7

1

3

High-throughput

0.536

High

1043297

HAS1
ATP-dependent RNA helicase HAS1

1

4

High-throughput

0.536

High

1059252

TSR1
Ribosome biogenesis protein TSR1

1

1

High-throughput

0.536

High

637291

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.513

High

758263

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.513

High

803947

CIC1
Proteasome-interacting protein CIC1

1

0

High-throughput

0.513

High

814398

NOC2
Nucleolar complex protein 2

1

0

High-throughput

0.513

High

816183

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.513

High

816915

NUG1
Nuclear GTP-binding protein NUG1

1

0

High-throughput

0.513

High

830192

NOP2
25S rRNA

1

0

High-throughput

0.513

High

843281

KRI1
Protein KRI1

1

0

High-throughput

0.513

High

865425

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.513

High

871066

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.513

High

871099

CCM1
Mitochondrial 15S rRNA processing factor CCM1

1

0

High-throughput

0.513

High

917491

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.513

High

919016

PESC
Pescadillo homolog

1

0

High-throughput

0.513

High

924645

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.513

High

1041883

RLI1
Translation initiation factor RLI1

1

0

High-throughput

0.513

High

1044596

HMO1
High mobility group protein 1

1

0

High-throughput

0.513

High

1046524

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.513

High

1047289

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.513

High

1059612

NOP12
Nucleolar protein 12

1

0

High-throughput

0.513

High

1059617

YTM1
Ribosome biogenesis protein YTM1

1

0

High-throughput

0.513

High

1059622

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.513

High

1059623

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.513

High

518143

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.500

High

381291

H2B1
Histone H2B.1

1

1

High-throughput

0.489

High

381653

H2B2
Histone H2B.2

1

1

High-throughput

0.489

High

518404

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.489

High

676777

GBP2
Serine/arginine

1

1

High-throughput

0.489

High

893239

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.489

High

1030587

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.489

High

1031062

NOP3
Serine/arginine

1

2

High-throughput

0.489

High

682400

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.479

High

721667

RENT1
ATP-dependent helicase NAM7

1

1

Small-scale

0.479

High

747607

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

1038760

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

1053523

UTP21
U3 small nucleolar RNA-associated protein 21

1

1

Small-scale

0.479

High

1055494

NOC4
Nucleolar complex protein 4

1

1

High-throughput

0.479

High

1059620

MAK21
Ribosome biogenesis protein MAK21

1

1

High-throughput

0.479

High

149978

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

410363

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

435394

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436197

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

442135

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

512166

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

512678

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

513780

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.458

High

513917

RS11B
Small ribosomal subunit protein uS17B

1

0

High-throughput

0.458

High

514859

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

674862

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

677971

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

753613

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

874556

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

1042249

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

1046804

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

1059624

EFG1P
rRNA-processing protein EFG1

1

0

High-throughput

0.458

High

1059625

RL11B
Large ribosomal subunit protein uL5B

1

0

High-throughput

0.458

High

645550

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.457

High

812985

IMDH1
Putative inosine-5'-monophosphate dehydrogenase 1

1

1

High-throughput

0.457

High

1025190

SEN1
Helicase SEN1

1

1

Small-scale

0.445

High

858080

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.437

High

780168

SDS22
Protein phosphatase 1 regulatory subunit SDS22

2

0

Small-scale

0.322

High

403673

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

0

Small-scale

0.310

High

584456

IDI1
Isopentenyl-diphosphate delta-isomerase

1

0

High-throughput

0.282

High

397538

CBP2
Cytochrome B pre-mRNA-processing protein 2

1

0

High-throughput

0.279

Low

454011

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.279

Low

592532

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.279

Low

645093

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.279

Low

740096

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

High-throughput

0.279

Low

743597

PT127
Putative mitochondrial translation system component PET127

1

0

High-throughput

0.279

Low

744778

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.279

Low

805227

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

0

High-throughput

0.279

Low

815253

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.279

Low

863189

YPP1
Cargo-transport protein YPP1

1

0

High-throughput

0.279

Low

917835

MNP1
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.279

Low

1039053

IMA1
Importin subunit alpha

1

0

High-throughput

0.279

Low

1053870

IMB1
Importin subunit beta-1

1

0

High-throughput

0.279

Low

1059610

ISA1
Iron-sulfur assembly protein 1

1

0

High-throughput

0.279

Low

850537

RRT5
Regulator of rDNA transcription protein 5

1

0

High-throughput

0.265

Low

686925

BUB3
Spindle assembly checkpoint protein BUB3

1

0

Small-scale

0.261

Low

450653

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.261

Low

555161

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

676986

SRO9
RNA-binding protein SRO9

1

0

High-throughput

0.261

Low

383202

RLA4
Large ribosomal subunit protein P2B

1

0

High-throughput

0.249

Low

383920

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433872

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

436533

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.249

Low

448339

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.249

Low

503268

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504440

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

511303

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

511495

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.249

Low

558877

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

570160

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.249

Low

594598

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

644999

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.249

Low

680107

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

708337

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

710011

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

735190

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

745893

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.249

Low

778561

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

780062

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

792273

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.249

Low

802414

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

808922

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

812704

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

825913

RL34B
Large ribosomal subunit protein eL34B

1

0

High-throughput

0.249

Low

918476

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

1033594

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1046315

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

1051992

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

Small-scale

0.249

Low

1053983

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

1059613

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

1059614

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

1059615

NCBP2
Nuclear cap-binding protein subunit 2

1

0

High-throughput

0.249

Low

1059618

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

924747

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low

365204

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low

394945

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

453821

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

575527

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

727355

HS104
Heat shock protein 104

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025