HitPredict

Interactor 1: LASP1 (Q14847)
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Gene: LASP1

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 389
+	Hs
		433354 LASP1_HUMAN (1-261): 1.82e-58: 188: 100.00		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		802603 LASP1_HUMAN (1-261): 1.82e-58: 188: 100.00		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		207835 PPIP1_HUMAN (3-261): 4.41e-28: 112: 15.47		SH24A_HUMAN (67-198): 1.19e-45: 164: 29.71
+	Hs
		433732 MYO1E_HUMAN (36-261): 8.28e-25: 105: 15.04		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		924563 ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		434085 BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		522981 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Xl
		60960 A5LHG3_XENLA (14-261): 4.67e-24: 103: 18.55		GRB2A_XENLA (56-256): 9.07e-50: 169: 15.89
+	Hs
		1332887 DBNL_HUMAN (59-261): 2.02e-25: 105: 23.65		SH24A_HUMAN (67-198): 1.19e-45: 164: 29.71
+	Hs
		433564 PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		924570 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Mm
		639446 SRC8_MOUSE (59-260): 8.14e-23: 99.2: 21.68		LYN_MOUSE (11-284): 1.16e-46: 168: 14.33
+	Hs
		433350 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		1151016 Q6FGM0_HUMAN (48-261): 6.99e-24: 100: 18.81		SH24A_HUMAN (67-198): 1.19e-45: 164: 29.71
+	Hs
		1307417 SH3G1_HUMAN (48-261): 6.99e-24: 100: 18.81		SH24A_HUMAN (67-198): 1.19e-45: 164: 29.71
+	Hs
		1052318 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		SH24A_HUMAN (67-198): 1.19e-45: 164: 29.71
+	Hs
		411992 PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Dm
		993202 Q9VDF4_DROME (102-261): 1.79e-26: 109: 24.59		GRAP_DROME (67-177): 4.19e-23: 97.9: 20.00
+	Hs
		796487 DBNL_HUMAN (59-261): 2.02e-25: 105: 23.65		ZAP70_HUMAN (86-222): 1.53e-17: 86.1: 20.98
+	Hs
		796571 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81