Protein: SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

Gene: SNU66
Organism: Saccharomyces cerevisiae S288C
Interactions: 88
UniProt ID: Q12420

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000481 - maturation of 5S rRNA
GO:0005634 - nucleus
GO:0005681 - spliceosomal complex
GO:0045292 - mRNA cis splicing, via spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1084900

HUB1
Ubiquitin-like modifier HUB1

5

2

Small-scale

0.931

High

751812

PRP8
Pre-mRNA-splicing factor 8

5

1

Small-scale

0.922

High

744185

BRR2
Pre-mRNA-splicing helicase BRR2

10

3

Small-scale

0.755

High

886363

PRP31
Pre-mRNA-processing factor 31

5

1

Small-scale

0.714

High

627883

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

5

4

Small-scale

0.712

High

1042464

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

4

1

Small-scale

0.691

High

625061

PRP6
Pre-mRNA-splicing factor 6

4

3

Small-scale

0.684

High

817185

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

2

Small-scale

0.683

High

820855

RUXG
Small nuclear ribonucleoprotein G

4

7

Small-scale

0.678

High

865294

LSM8
LSM2-LSM8 complex subunit LSM8

4

8

Small-scale

0.678

High

945364

LSM3
LSM complex subunit LSM3

4

11

Small-scale

0.672

High

924568

LSM7
LSM complex subunit LSM7

3

9

Small-scale

0.662

High

797329

SP381
Pre-mRNA-splicing factor SPP381

4

0

Small-scale

0.661

High

795950

LSM2
LSM complex subunit LSM2

3

5

Small-scale

0.656

High

818073

LSM4
LSM complex subunit LSM4

3

2

Small-scale

0.656

High

780244

SN114
Pre-mRNA-splicing factor SNU114

3

1

Small-scale

0.650

High

847849

SMD3
Small nuclear ribonucleoprotein Sm D3

3

5

Small-scale

0.650

High

1054951

LSM6
LSM complex subunit LSM6

2

3

Small-scale

0.611

High

584400

GCN2
eIF-2-alpha kinase GCN2

2

0

High-throughput

0.595

High

739289

PRP21
Pre-mRNA-splicing factor PRP21

2

1

Small-scale

0.584

High

933159

RUXF
Small nuclear ribonucleoprotein F

2

3

Small-scale

0.584

High

1036193

SMD1
Small nuclear ribonucleoprotein Sm D1

2

1

Small-scale

0.584

High

1054399

SMD2
Small nuclear ribonucleoprotein Sm D2

2

1

Small-scale

0.584

High

1059220

PRP11
Pre-mRNA-splicing factor PRP11

2

1

Small-scale

0.584

High

1084787

RUXE
Small nuclear ribonucleoprotein E

2

1

Small-scale

0.584

High

739227

PRP19
Pre-mRNA-processing factor 19

2

3

Small-scale

0.571

High

1026954

PRP38
Pre-mRNA-splicing factor 38

2

0

Small-scale

0.559

High

1057089

DIB1
Spliceosomal protein DIB1

2

0

Small-scale

0.559

High

1065585

RU2A
U2 small nuclear ribonucleoprotein A'

2

0

Small-scale

0.559

High

1084831

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

0

Small-scale

0.559

High

738280

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

2

2

High-throughput

0.537

High

567736

MSI1
Histone-binding protein MSI1

1

2

High-throughput

0.536

High

794020

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

3

High-throughput

0.536

High

1060065

PSR1
Phosphatase PSR1

1

1

Small-scale

0.535

High

580281

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.521

High

687095

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

0

High-throughput

0.513

High

923230

NOG2
Nucleolar GTP-binding protein 2

1

0

Small-scale

0.486

High

850301

SAD1
Pre-mRNA-splicing factor SAD1

1

1

Small-scale

0.481

High

393556

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

750327

PRP40
Pre-mRNA-processing protein PRP40

1

2

Small-scale

0.479

High

757560

NCBP1
Nuclear cap-binding protein complex subunit 1

1

1

Small-scale

0.479

High

813380

PRP39
Pre-mRNA-processing factor 39

1

3

Small-scale

0.479

High

816568

SNU13
13 kDa ribonucleoprotein-associated protein

1

2

Small-scale

0.479

High

818497

LSM5
LSM complex subunit LSM5

1

1

Small-scale

0.479

High

826558

MSL1
U2 small nuclear ribonucleoprotein B''

1

4

Small-scale

0.479

High

892803

SF3B1
U2 snRNP component HSH155

1

2

Small-scale

0.479

High

917517

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

1

Small-scale

0.479

High

1028005

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

1

Small-scale

0.479

High

1043519

CEF1
Pre-mRNA-splicing factor CEF1

1

1

Small-scale

0.479

High

1065118

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.479

High

1084745

CLF1
Pre-mRNA-splicing factor CLF1

1

3

Small-scale

0.479

High

697401

MIG1
Regulatory protein MIG1

1

0

Small-scale

0.460

High

1039076

IMA1
Importin subunit alpha

1

0

Small-scale

0.460

High

501748

YSF3
RDS3 complex subunit 10

1

0

Small-scale

0.458

High

625150

PRP9
Pre-mRNA-splicing factor PRP9

1

0

Small-scale

0.458

High

646579

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

680181

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

708594

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

743567

RU1A
U1 small nuclear ribonucleoprotein A

1

0

Small-scale

0.458

High

781598

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

796476

SLT11
Pre-mRNA-splicing factor SLT11

1

0

Small-scale

0.458

High

826954

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

918235

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

Small-scale

0.458

High

1025668

NAM8
Protein NAM8

1

0

Small-scale

0.458

High

1037769

CUS1
Cold sensitive U2 snRNA suppressor 1

1

0

Small-scale

0.458

High

1044071

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

1

0

Small-scale

0.458

High

1047400

RSE1
Pre-mRNA-splicing factor RSE1

1

0

Small-scale

0.458

High

1057309

RDS3
Pre-mRNA-splicing factor RDS3

1

0

Small-scale

0.458

High

1059556

LUC7
Protein LUC7

1

0

Small-scale

0.458

High

1084119

MDN1
Midasin

1

0

High-throughput

0.458

High

1084472

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1084901

HSH49
Protein HSH49

1

0

Small-scale

0.458

High

481819

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

525621

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

528080

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

742729

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

742990

HSP79
Heat shock protein homolog SSE2

1

4

High-throughput

0.445

High

804578

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

815781

SAP1
Protein SAP1

1

1

Small-scale

0.439

High

1060852

PSR2
Probable phosphatase PSR2

1

1

Small-scale

0.439

High

638941

CBP3
Protein CBP3, mitochondrial

1

0

Small-scale

0.251

Low

739113

PT309
Mitochondrial COX1 translation regulator PET309

1

0

Small-scale

0.251

Low

1084893

MPC70
Sporulation-specific protein 21

1

0

Small-scale

0.251

Low

416311

SYWM
Tryptophan--tRNA ligase, mitochondrial

1

0

High-throughput

0.238

Low

671748

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low

739494

ZUO1
Zuotin

1

0

High-throughput

0.232

Low

752909

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

816483

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025