HitPredict

Interactor 1: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	24457600, 27634302, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 2115 Hs			1 746
+	Hs
		724847 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		725169 MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1068540 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		1149802 PLEC_MOUSE (21-1207): 2.95e-35: 150: 12.47		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Hs
		1034582 GOGA4_HUMAN (5-528): 2.18e-12: 75: 11.24		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		331814 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		1061253 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		1061250 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		SUV92_HUMAN (447-734): 5.41e-74: 247: 24.10
+	Hs
		203688 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		975254 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		331816 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		331711 TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		828622 CENPF_HUMAN (1458-2037): 1.6e-10: 69.3: 9.97		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		1068676 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		ASH1L_HUMAN (547-732): 3.87e-57: 214: 30.85