Protein: CHOLN
Protein cholesin

Gene: CHOLN, CHLSN
Organism: Homo sapiens
Interactions: 195
UniProt ID: Q9BRJ6

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005179 - hormone activity
GO:0005615 - extracellular space
GO:0045541 - negative regulation of cholesterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1411198

THAP1
THAP domain-containing protein 1

3

1

High-throughput

0.616

High

1008861

RED1
Double-stranded RNA-specific editase 1

2

1

High-throughput

0.611

High

898788

RL14
Large ribosomal subunit protein eL14

2

0

High-throughput

0.602

High

1411194

LN28A
Protein lin-28 homolog A

2

1

High-throughput

0.601

High

961823

RL37A
Large ribosomal subunit protein eL43

2

0

High-throughput

0.585

High

979181

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.585

High

986175

RL8
Large ribosomal subunit protein uL2

2

0

High-throughput

0.585

High

1411201

LYAR
Cell growth-regulating nucleolar protein

2

0

High-throughput

0.585

High

422996

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.577

High

1087518

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

1037340

H11
Histone H1.1

2

1

High-throughput

0.558

High

228743

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

1

High-throughput

0.536

High

287111

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

3

High-throughput

0.536

High

288749

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.536

High

447370

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

521898

H14
Histone H1.4

1

1

High-throughput

0.536

High

1006660

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.536

High

1061121

SRSF1
Serine/arginine-rich splicing factor 1

1

1

High-throughput

0.536

High

1099503

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.536

High

1161628

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.536

High

1402547

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

872685

SOX2
Transcription factor SOX-2

2

2

High-throughput

0.533

High

998745

H31
Histone H3.1

2

1

High-throughput

0.533

High

141074

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

290699

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.513

High

428942

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.513

High

530297

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

542633

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

615945

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.513

High

686378

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

785403

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

824319

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

842501

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

854263

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

859423

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

859972

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

884214

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

908455

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

951384

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

969395

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

975901

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.513

High

977064

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.513

High

982532

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.513

High

984521

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

985540

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

985846

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

992066

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.513

High

1016187

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1037614

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1127474

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.513

High

1152230

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1275639

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.513

High

1288241

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1386486

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.513

High

1395808

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1409817

RBM4B
RNA-binding protein 4B

1

0

High-throughput

0.513

High

1410711

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1411191

REXO4
RNA exonuclease 4

1

0

High-throughput

0.513

High

1411206

IL17B
Interleukin-17B

1

0

High-throughput

0.513

High

1411208

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

1411209

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1411211

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1411214

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.513

High

1411217

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

705532

GRN
Progranulin

1

0

High-throughput

0.493

High

239989

SOX15
Transcription factor SOX-15

1

2

High-throughput

0.489

High

659290

SP100
Nuclear autoantigen Sp-100

1

2

High-throughput

0.489

High

833172

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.489

High

1051043

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.489

High

1411215

SRPK3
SRSF protein kinase 3

1

2

High-throughput

0.489

High

248340

HBP1
HMG box-containing protein 1

1

3

High-throughput

0.479

High

346253

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

900127

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.479

High

1088532

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1207426

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

1280451

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1334842

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

445592

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

473024

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

620553

NUCL
Nucleolin

1

0

High-throughput

0.458

High

644017

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

675652

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

693939

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

810325

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

916030

NUP98
Nuclear pore complex protein Nup98-Nup96

1

0

High-throughput

0.458

High

980226

H4
Histone H4

1

0

High-throughput

0.458

High

1138566

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1194335

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1290684

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1411190

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1411202

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1399997

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

2

High-throughput

0.457

High

1056936

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.445

High

132269

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.437

High

143221

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.437

High

339840

KLF8
Krueppel-like factor 8

1

5

High-throughput

0.437

High

348190

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

4

High-throughput

0.437

High

372994

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

396826

ESR1
Estrogen receptor

1

1

High-throughput

0.437

High

406569

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

474245

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.437

High

640274

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.437

High

832566

ETV3
ETS translocation variant 3

1

1

High-throughput

0.437

High

877552

LHX1
LIM/homeobox protein Lhx1

1

3

High-throughput

0.437

High

895790

LHX2
LIM/homeobox protein Lhx2

1

3

High-throughput

0.437

High

902034

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.437

High

1017165

H33
Histone H3.3

1

1

High-throughput

0.437

High

1087684

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

1

High-throughput

0.437

High

1087978

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.437

High

1118675

KLF9
Krueppel-like factor 9

1

5

High-throughput

0.437

High

1132935

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.437

High

1255277

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1257116

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.437

High

1326431

MINK1
Misshapen-like kinase 1

1

2

High-throughput

0.437

High

1351141

SP7
Transcription factor Sp7

1

6

High-throughput

0.437

High

1367136

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1379939

LHX4
LIM/homeobox protein Lhx4

1

3

High-throughput

0.437

High

1405724

KLF6
Krueppel-like factor 6

1

5

High-throughput

0.437

High

1411188

THAP7
THAP domain-containing protein 7

1

1

High-throughput

0.437

High

1411189

KLF16
Krueppel-like factor 16

1

5

High-throughput

0.437

High

1411192

SOX17
Transcription factor SOX-17

1

2

High-throughput

0.437

High

1411197

STRN4
Striatin-4

1

1

High-throughput

0.437

High

1411203

LHX3
LIM/homeobox protein Lhx3

1

3

High-throughput

0.437

High

1411204

DUX4
Double homeobox protein 4

1

3

High-throughput

0.437

High

1411207

KLF15
Krueppel-like factor 15

1

5

High-throughput

0.437

High

1411210

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

1411213

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.437

High

1411218

KLF12
Krueppel-like factor 12

1

5

High-throughput

0.437

High

1411219

MAFB
Transcription factor MafB

1

1

High-throughput

0.437

High

430292

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1411212

AKP8L
A-kinase anchor protein 8-like

1

0

High-throughput

0.426

High

1411196

ANLN
Anillin

2

0

High-throughput

0.305

High

1154573

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.282

High

191780

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.279

Low

338945

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.279

Low

340225

PCNT
Pericentrin

1

0

High-throughput

0.279

Low

909162

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.279

Low

1038472

TIE2
Angiopoietin-1 receptor

1

0

High-throughput

0.279

Low

1112689

CUL1
Cullin-1

1

0

High-throughput

0.279

Low

1178080

RN151
RING finger protein 151

1

0

High-throughput

0.279

Low

1291169

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.279

Low

1313130

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.279

Low

1361086

MYO3B
Myosin-IIIb

1

0

High-throughput

0.279

Low

1361744

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.279

Low

1370335

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.279

Low

1390590

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.279

Low

1395696

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1398121

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

1411205

ZBT47
Zinc finger and BTB domain-containing protein 47

1

0

High-throughput

0.279

Low

1411216

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

722741

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

High-throughput

0.269

Low

301664

WFS1
Wolframin

1

0

High-throughput

0.268

Low

843922

HD
Huntingtin

1

0

High-throughput

0.268

Low

106561

APRIO
Alternative prion protein

1

0

Small-scale

0.261

Low

404890

PRIO
Major prion protein

1

0

Small-scale

0.261

Low

1349759

FBX25
F-box only protein 25

1

0

Small-scale

0.261

Low

129375

MEN1
Menin

1

0

High-throughput

0.249

Low

180030

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

194318

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

226591

TLX2
T-cell leukemia homeobox protein 2

1

0

High-throughput

0.249

Low

294249

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

315948

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

412518

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

589541

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696347

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

711186

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

High-throughput

0.249

Low

766800

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

769020

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

787073

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.249

Low

846930

ETV4
ETS translocation variant 4

1

0

High-throughput

0.249

Low

861268

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.249

Low

937880

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

938497

PAX9
Paired box protein Pax-9

1

0

High-throughput

0.249

Low

942847

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

970988

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

976519

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

1035874

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.249

Low

1037890

HEN1
Helix-loop-helix protein 1

1

0

High-throughput

0.249

Low

1121320

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

1328930

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

1330916

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.249

Low

1352717

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1380121

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.249

Low

1385847

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

1393153

PRR11
Proline-rich protein 11

1

0

High-throughput

0.249

Low

1393641

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1404728

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.249

Low

1411193

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

1411195

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1411199

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

1411200

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

401387

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.232

Low

1032858

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.232

Low

1288445

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.232

Low

1326059

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025