HitPredict

Interactor 1: NR1I3 (Q14994)
Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)
Gene: NR1I3

Interactor 2: MED17 (Q9NVC6)
Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)
Gene: MED17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 352 Hs			1 651
+	Hs
		782672 HNF4A_HUMAN (2-351): 3.85e-101: 308: 24.43		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Hs
		370538 ESR1_HUMAN (2-351): 1.82e-94: 294: 21.66		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Mm
		1142698 ERR2_MOUSE (7-351): 8.22e-91: 280: 23.63		MED17_MOUSE (1-651): 0: 1033: 95.70
+	Hs
		1269737 ESR2_HUMAN (2-352): 4.23e-88: 276: 21.76		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Hs
		500448 THA_HUMAN (6-325): 1.13e-39: 148: 32.16		MED17_HUMAN (1-651): 0: 1032: 100.00